Evidence map›Paper›PMID 38645088›Full record

ArticleResearch square2024

Multi-scale in vivo imaging of tumour development using a germline conditional triple-reporter system.

Piotr Dzien, Ximena Raffo Iraolagoitia, Stephanie May, David Stevenson, Lynn McGarry, Dmitry Soloviev, Gavin Brown, Colin Nixon, Chrysa Kapeni, Maike De La Roche and 7 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Piotr DzienCancer Research UK Scotland Institute.
Ximena Raffo IraolagoitiaCancer Research UK Scotland Institute.
Stephanie MayCancer Research UK Scotland Institute.
David StevensonCancer Research UK Scotland Institute.
Lynn McGarryCancer Research UK Scotland Institute.
Dmitry SolovievCancer Research UK Scotland Institute.
Gavin BrownCancer Research UK Scotland Institute.
Colin NixonCancer Research UK Scotland Institute.
Chrysa KapeniCancer Research UK Cambridge Institute.
Maike De La RocheCancer Research UK Cambridge Institute.
Karen BlythCRUK Scotland Institute.ORCID 0000-0002-9304-439X
Scott LyonsCold Spring Harbor Laboratory.
Thomas BirdCancer Research UK Scotland Institute.
Douglas StrathdeeCancer Research UK Scotland Institute.
Gilbert FruhwirthKings College London.ORCID 0000-0002-1438-2674
Leo CarlinCancer Research UK Scotland Institute.
David LewisCancer Research UK Scotland Institute.ORCID 0000-0001-9329-1326
King's College London · GBCancer Research UK · GBCancer Research UK Cambridge Center · GBKing's College - North Carolina · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M
NCI NIH HHS P30 CA045508Wellcome Trust
6 · The paper itself

Abstract

Imaging reporter genes are indispensable for visualising biological processes in living subjects, particularly in cancer research where they have been used to observe tumour development, cancer cell dissemination, and treatment response. Engineering reporter genes into the germline frequently involves single imaging modality reporters operating over limited spatial scales. To address these limitations, we developed an inducible triple-reporter mouse model (Rosa26

Identifiers

PMID38645088
PMCPMC11030518
OpenAlexW4393900054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.