OrthoFusion: A Super-Resolution Algorithm to Fuse Orthogonal CT Volumes.

OrthoFusion, an intuitive super-resolution algorithm, is presented in this study to enhance the spatial resolution of clinical CT volumes. The efficacy of OrthoFusion is evaluated, relative to high-resolution CT volumes (ground truth), by assessing image volume and derived bone morphological similarity, as well as its performance in specific applications in 2D-3D registration tasks. Results demonstrate that OrthoFusion significantly reduced segmentation time, while improving structural similarity of bone images and relative accuracy of derived bone model geometries. Moreover, it proved beneficial in the context of biplane videoradiography, enhancing the similarity of digitally reconstructed radiographs to radiographic images and improving the accuracy of relative bony kinematics. OrthoFusion's simplicity, ease of implementation, and generalizability make it a valuable tool for researchers and clinicians seeking high spatial resolution from existing clinical CT data. This study opens new avenues for retrospectively utilizing clinical images for research and advanced clinical purposes, while reducing the need for additional scans, mitigating associated costs and radiation exposure.