Evidence map›Paper›PMID 38645057›Full record

ArticlebioRxiv : the preprint server for biology2024

The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins.

Anjali Sandhu, Xiaohui Lyu, Xinghaoyun Wan, Xuefeng Meng, Ngang Heok Tang, Gilberto Gonzalez, Ishana N Syed, Lizhen Chen, Yishi Jin, Andrew D Chisholm

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Anjali SandhuDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093 USA.
Xiaohui LyuDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093 USA.
Xinghaoyun WanDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093 USA.
Xuefeng MengDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093 USA.
Ngang Heok TangDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, CA 92093 USA.
Gilberto GonzalezBarshop Institute for Longevity and Aging Studies, Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Ishana N SyedBarshop Institute for Longevity and Aging Studies, Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Lizhen ChenBarshop Institute for Longevity and Aging Studies, Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Yishi JinDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093 USA.ORCID 0000-0002-9371-9860
Andrew D ChisholmDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093 USA.
University of California System · USThe University of Texas Health Science Center at San Antonio · USUniversity of California San Diego · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular genetics of axon and synapse development and maintenanceR35NS127314 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yishi Jin · 2022 to 2026
$4.3M
Cytoskeletal dynamics in axon regenerationR01NS093588 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHISHOLM, ANDREW D, JIN, YISHI · 2015 to 2023
$3.7M
The role of CELF2 and its genetic variants in Alzheimer's diseaseR01AG070214 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHEN, LIZHEN · 2021 to 2025
$2.2M
Maintenance and Repair of the C. elegans SkinR35GM134970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHISHOLM, ANDREW D · 2020 to 2024
$2.1M
Neuronal microtubule regulation and agingR01AG071591 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lizhen Chen · 2021 to 2026
$1.6M
NIA NIH HHS R01 AG070214NIA NIH HHS R01 AG071591NIGMS NIH HHS R35 GM134970NIH HHS P40 OD010440NINDS NIH HHS R01 NS093588NINDS NIH HHS R35 NS127314
6 · The paper itself

Abstract

Microtubules (MTs) are dynamic components of the cytoskeleton and play essential roles in morphogenesis and maintenance of tissue and cell integrity. Despite recent advances in understanding MT ultrastructure, organization, and growth control, how cells regulate MT organization at the cell cortex remains poorly understood. The EFA-6/EFA6 proteins are recently identified membrane-associated proteins that inhibit cortical MT dynamics. Here, combining visualization of endogenously tagged

Indexed as

biomolecular condensatesembryosepidermisgerm cellsmicrotubule end binding proteinsneuronsTACCtubulin chaperone

Identifiers

PMID38645057
PMCPMC11030407
OpenAlexW4394817719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.