Evidence map›Paper›PMID 38645040›Full record

ArticlebioRxiv : the preprint server for biology2024

Joseph Lee, Antoine Gleizes, Felipe Takaesu, Sarah F Webster, Taylor Hailstock, Nick Barker, Adam D Gracz

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Joseph LeeDepartment of Medicine, Division of Digestive Diseases, Emory University.ORCID 0009-0009-7376-2114
Antoine GleizesDepartment of Medicine, Division of Digestive Diseases, Emory University.ORCID 0009-0002-5490-7743
Felipe TakaesuGraduate Program in Biochemistry, Cell and Developmental Biology, Emory University.ORCID 0000-0002-5569-8907
Sarah F WebsterGraduate Program in Biochemistry, Cell and Developmental Biology, Emory University.ORCID 0000-0002-9716-3249
Taylor HailstockGraduate Program in Biochemistry, Cell and Developmental Biology, Emory University.ORCID 0000-0002-1849-100X
Nick BarkerInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0003-3566-4475
Adam D GraczDepartment of Medicine, Division of Digestive Diseases, Emory University.ORCID 0000-0003-1298-568X
Emory University · USAgency for Science, Technology and Research · SG

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Regulation of intestinal stem cell state by ID3R35GM142503 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam David Gracz · 2021 to 2026
$2.5M
NCATS NIH HHS UL1 TR000454NIGMS NIH HHS R35 GM142503
6 · The paper itself

Abstract

Progenitors and mature cells can maintain the intestinal epithelium by dedifferentiation and facultative intestinal stem cell (fISC) function when active ISCs (aISCs) are lost to damage. Here, we sought to model fISC activation in intestinal organoids with doxorubicin (DXR), a chemotherapeutic known to ablate

Identifiers

PMID38645040
PMCPMC11030406
OpenAlexW4394718001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.