Evidence map›Paper›PMID 38645005›Full record

ArticlebioRxiv : the preprint server for biology2024

Genetic Analysis and Functional Assessment of a

Jes-Rite Michaels, Ammar Husami, Andrew M Vontell, Samantha A Brugmann, Rolf W Stottmann

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jes-Rite MichaelsSteve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Ammar HusamiDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45215, USA.
Andrew M VontellSteve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Samantha A BrugmannDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45215, USA.
Rolf W StottmannSteve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0003-4512-6806
Nationwide Children's Hospital · USCincinnati Children's Hospital Medical Center · US

Funding

Harnessing the therapeutic potential of neural crest cells by manipulating the primary ciliumR35DE027557 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUGMANN, SAMANTHA A · 2017 to 2024
$7.6M
Forward genetic analysis of congenital craniofacial malformationsR01DE027091 · NIDCR · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI STOTTMANN, ROLF W · 2019 to 2023
$2.9M
NIDCR NIH HHS R01 DE027091NIDCR NIH HHS R35 DE027557
6 · The paper itself

Abstract

Cleft lip and cleft palate are among the most common congenital anomalies and are the result of incomplete fusion of embryonic craniofacial processes or palatal shelves, respectively. We know that genetics play a large role in these anomalies but the list of known causal genes is far from complete. As part of a larger sequencing effort of patients with micrognathia and cleft palate we identified a candidate variant in

Indexed as

Cleft palateCRISPRMicrognathiaPierre-Robin SequenceTGFBR2

Identifiers

PMID38645005
PMCPMC11030355
OpenAlexW4394719521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.