Evidence map›Paper›PMID 38645001›Full record

ArticlebioRxiv : the preprint server for biology2024

Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.

Mirza Muhammad Fahd Qadir, Ruth M Elgamal, Keijing Song, Parul Kudtarkar, Siva S V P Sakamuri, Prasad V Katakam, Samir El-Dahr, Jay Kolls, Kyle J Gaulton, Franck Mauvais-Jarvis

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mirza Muhammad Fahd QadirSection of Endocrinology and Metabolism, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.ORCID 0000-0002-6764-6151
Ruth M ElgamalBiomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-9183-9386
Keijing SongCenter for Translational Research in Infection and Inflammation, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Parul KudtarkarDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Siva S V P SakamuriDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID 0000-0003-3569-9985
Prasad V KatakamDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.
Samir El-DahrDepartment of Pediatrics, Tulane University, School of Medicine, New Orleans, LA, USA.ORCID 0000-0001-7571-4292
Jay KollsCenter for Translational Research in Infection and Inflammation, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.ORCID 0000-0001-5151-6304
Kyle J GaultonDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-1318-7161
Franck Mauvais-JarvisSection of Endocrinology and Metabolism, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.ORCID 0000-0002-0874-0754
Tulane University · USUniversity of California San Diego · US

Funding

The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6M
The next iteration of the AMP-T2D Knowledge PortalUM1DK105554 · NIDDK · BROAD INSTITUTE, INC. · PI BOEHNKE, MICHAEL L, BURTT, NOEL P · 2020 to 2025
$18.5M
Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
Proposal for the AMP T2D-GENES Data Coordination Center and Web PortalU01DK105554 · NIDDK · BROAD INSTITUTE, INC. · PI FLOREZ, JOSE CARLOS · 2015 to 2019
$16.8M
The impact of genomic variation on environment-induced changes in pancreatic beta cell statesU01HG012059 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hannah Kathryn Carter, Kyle Jeffrie Gaulton · 2021 to 2026
$7.5M
Targeting the estrogen receptor-α to protect functional β-cell mass in womenR01DK074970 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Franck Mauvais-Jarvis · 2007 to 2026
$6.0M
Single cell analysis of the human pancreas in type 1 diabetesU01DK120429 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE, SANDER, MAIKE · 2018 to 2021
$3.1M
Diabetes risk variants affecting transcription factor-regulated cellular networksR01DK114650 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE · 2018 to 2022
$1.9M
Role of the Androgen Receptor in Insulin Secretion in the MaleI01BX005812 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI MAUVAIS-JARVIS, FRANCK · 2023 to 2025
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BLRD VA I01 BX005812NHGRI NIH HHS U01 HG012059NIDDK NIH HHS R01 DK074970NIDDK NIH HHS R01 DK114650NIDDK NIH HHS U01 DK105554NIDDK NIH HHS U01 DK120429NIDDK NIH HHS UC4 DK098085NIDDK NIH HHS UM1 DK105554
6 · The paper itself

Abstract

Biological sex affects the pathogenesis of type 2 and type 1 diabetes (T2D, T1D) including the development of β cell failure observed more often in males. The mechanisms that drive sex differences in β cell failure is unknown. Studying sex differences in islet regulation and function represent a unique avenue to understand the sex-specific heterogeneity in β cell failure in diabetes. Here, we examined sex and race differences in human pancreatic islets from up to 52 donors with and without T2D (including 37 donors from the Human Pancreas Analysis Program [HPAP] dataset) using an orthogonal series of experiments including single cell RNA-seq (scRNA-seq), single nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), dynamic hormone secretion, and bioenergetics. In cultured islets from nondiabetic (ND) donors, in the absence of the

Indexed as

DiabetesIsletMultiomicsscRNAseqSex DifferencessnATACseqSystems Biologyβ cell

Identifiers

PMID38645001
PMCPMC11030320
OpenAlexW4394797355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.