Estradiol induces bone osteolysis in triple-negative breast cancer via its membrane-associated receptor ERα36.

D Joshua Cohen, Cydney D Dennis, Jingyao Deng, Barbara D Boyan, Zvi Schwartz

Open access · goldAbstract read

In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

1.4field-weighted citation impact, top 16% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

24R,25(OH)International journal of cancer · 2026
Article
Non-Canonical Wnt16 and microRNA-145 Mediate the Response of Human Bone Marrow Stromal Cells to Additively Manufactured Porous 3-Dimensional Biomimetic Titanium-Aluminum-Vanadium Constructs.Cells · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

D Joshua CohenDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.ORCID https://orcid.org/0000-0003-1212-6164

Cydney D DennisDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.

Jingyao DengDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.

Barbara D BoyanDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.

Zvi SchwartzDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.

Virginia Commonwealth University · USGeorgia Institute of Technology · USThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is thought to be an estradiol-independent, hormone therapy-resistant cancer because of lack of estrogen receptor alpha 66 (ERα66). We identified a membrane-bound splice variant, ERα36, in TNBC cells that responds to estrogen (E

Indexed as

bone resorptionbone–tumor interfacecross-talkERα36estrogenosteoclastsosteolysisSERMstumor–induced bone disease

Identifiers

PMID38644978

DOI10.1093/jbmrpl/ziae041

PMCPMC11032217

OpenAlexW4394990490

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.