Evidence map›Paper›PMID 38644935›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2024

Impact of Everolimus Initiation and Corticosteroid Weaning During Acute Phase After Heart Transplantation on Clinical Outcome: Data from the Korean Organ Transplant Registry (KOTRY).

Kyu-Sun Lee, Hyungseop Kim, Sun Hwa Lee, Dong-Ju Choi, Minjae Yoon, Eun-Seok Jeon, Jin-Oh Choi, Jeehoon Kang, Hae-Young Lee, Sung-Ho Jung and 7 more

Open access · goldAbstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 1 country.

Kyu-Sun LeeDepartment of Internal Medicine and Division of Cardiology, Eulji University Hospital and Eulji University School of Medicine, Daejeon, Republic of Korea.
Hyungseop KimDivision of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea.
Sun Hwa LeeDivision of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea.
Dong-Ju ChoiCardiovascular Center, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Minjae YoonCardiovascular Center, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Eun-Seok JeonDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Republic of Korea.
Jin-Oh ChoiDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Republic of Korea.
Jeehoon KangDepartment of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Republic of Korea.
Hae-Young LeeDepartment of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Republic of Korea.
Sung-Ho JungDepartment of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Jaewon OhDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Seok-Min KangDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Soo Yong LeeDivision of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Min Ho JuDepartment of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Jae-Joong KimDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine Seoul, Seoul, Republic of Korea.
Myoung Soo KimDeparment of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hyun-Jai ChoDepartment of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Republic of Korea.
Government of the Republic of Korea · KREulji University · KRKeimyung University Dongsan Medical Center · KRPusan National University Yangsan Hospital · KRSamsung Medical Center · KRSeoul National University Hospital · KRSungkyunkwan University · KRUlsan College · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of changes in immunosuppressive therapy during the acute phase post-heart transplantation (HTx) on clinical outcomes remains unclear. This study aimed to investigate the effects of changes in immunosuppressive therapy by corticosteroid (CS) weaning and everolimus (EVR) initiation during the first year post-HTx on clinical outcomes. We analyzed 622 recipients registered in the Korean Organ Transplant Registry (KOTRY) between January 2014 and December 2021. The median age at HTx was 56 years (interquartile range [IQR], 45-62), and the median follow-up time was 3.9 years (IQR 2.0-5.1). The early EVR initiation within the first year post-HTx and maintenance during the follow-up is associated with reduced the risk of primary composite outcome (all-cause mortality or re-transplantation) (HR, 0.24; 95% CI 0.09-0.68;

Indexed as

Adrenal Cortex HormonesEverolimusGraft RejectionHeart TransplantationImmunosuppressive AgentsRegistriesFemaleGraft SurvivalHumansMaleMiddle AgedRepublic of KoreaRetrospective StudiesTreatment OutcomeAdrenal Cortex HormonesEverolimusImmunosuppressive Agentscardiac allograft vasculopathyheart transplantationKorean Organ Transplant RegistrymTOR inhibitorprimary outcomerejectionsteroid weaning

Identifiers

PMID38644935
PMCPMC11028401
OpenAlexW4393997159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.