Evidence map›Paper›PMID 38644654›Full record

ArticleObesity (Silver Spring, Md.)2024

Maternal obesity: sex-specific in utero changes in fetal brain autophagy and mTOR.

Nana Merabova, Lierni Ugartemendia, Andrea G Edlow, Claudia Ibarra, Nune Darbinian, Gabriel Tatevosian, Laura Goetzl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Nana MerabovaDepartment of Family Medicine, Medical College of Wisconsin-Prevea, Green Bay, Wisconsin, USA.
Lierni UgartemendiaDepartment of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School at University of Texas Health Science Center at Houston, Houston, Texas, USA.
Andrea G EdlowDepartment of Obstetrics and Gynecology, Massachusetts General Hospital, Vincent Center for Reproductive Biology, Boston, Massachusetts, USA.ORCID 0000-0003-2915-5949
Claudia IbarraDepartment of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School at University of Texas Health Science Center at Houston, Houston, Texas, USA.
Nune DarbinianShriners Pediatric Research Center, Center for Neural Repair and Rehabilitation, Temple University, Philadelphia, Pennsylvania, USA.
Gabriel TatevosianShriners Pediatric Research Center, Center for Neural Repair and Rehabilitation, Temple University, Philadelphia, Pennsylvania, USA.
Laura GoetzlDepartment of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School at University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0003-4130-2809
The University of Texas Health Science Center · USShriners Hospitals for Children - Philadelphia · USMassachusetts General Hospital · USMedical College of Wisconsin · US

Funding

Gestational Age Variation in Human Placental Transport MechanismsR01HD069238 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI DEVANE, C LINDSAY LINDSAY, GOETZL, LAURA · 2012 to 2016
$2.8M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD069238Grand Challenges in Global Health OPP1119489NICHD NIH HHS R01 HD069238
6 · The paper itself

Abstract

objectiveMaternal obesity affects 39.7% of reproductive-age women in the United States. Emerging research has suggested that in utero exposure to maternal obesity is associated with adverse neurodevelopmental outcomes, but knowledge of underlying mechanisms in human samples is lacking.

methodsA matched case-control study was performed in women with singleton fetuses who were undergoing elective pregnancy termination at gestational ages 15 to 21 weeks. Maternal adiponectin levels from plasma were measured using ELISA kits. RNA was extracted from fetal brain tissue using RNeasy Mini Kit (QIAGEN). mRNA expression from ADIPOR1, ADIPOR2, MTOR, ATG5, ATG7, BECN1, and MAP1LC3B was quantified through the ΔΔCt method and using GAPDH as a housekeeping gene.

resultsWe have identified transcription patterns associated with inhibition of autophagy in male fetal brain tissue exposed to maternal obesity (↑MTOR, ↓ATG5, ↓ATG7, and ↓MAP1LC3B), with female fetuses demonstrating either no change in transcription or nonsignificant changes associated with increased autophagy. There was significant downregulation of the autophagy-associated gene BECN1 in both male and female individuals who were exposed to obesity in utero.

conclusionsWe present novel evidence suggesting that in utero exposure to maternal obesity in humans may significantly affect neurodevelopment, especially in male fetuses, through alterations in normal autophagy molecular mechanisms and with adiponectin as a potential mediator.

Indexed as

AdiponectinAutophagyBeclin-1BrainMicrotubule-Associated ProteinsPregnancy in ObesityTOR Serine-Threonine KinasesAdultAutophagy-Related Protein 5Autophagy-Related Protein 7Case-Control StudiesDown-RegulationFemaleFetusGestational AgeHumansAdiponectinATG5 protein, humanATG7 protein, humanAutophagy-Related Protein 5Autophagy-Related Protein 7Beclin-1BECN1 protein, humanMAP1LC3B protein, humanMicrotubule-Associated ProteinsMTOR protein, humanReceptors, AdiponectinRNA, MessengerTOR Serine-Threonine Kinases

Identifiers

PMID38644654
PMCPMC13521604
OpenAlexW4395005726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.