Evidence map›Paper›PMID 38644561›Full record

ArticleCNS neuroscience & therapeutics2024

Brain activation and connection across resting and motor-task states in patients with generalized tonic-clonic seizures.

Sisi Jiang, Yuehan Wang, Haonan Pei, Hechun Li, Junxia Chen, Yutong Yao, Qifu Li, Dezhong Yao, Cheng Luo

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sisi JiangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Yuehan WangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Haonan PeiThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Hechun LiThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Junxia ChenThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Yutong YaoDepartment of Neurosurgey, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, P. R. China.ORCID 0000-0002-6368-8856
Qifu LiDepartment of Neurology, Hainan Medical University, Hainan, P. R. China.
Dezhong YaoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Cheng LuoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.ORCID 0000-0003-0524-5886
University of Electronic Science and Technology of China · CNHainan Medical University · CN

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-5-039China Postdoctoral Science Foundation 2021TQ0061National Natural Science Foundation of China 61933003National Natural Science Foundation of China 62201133National Natural Science Foundation of China 81960249National Natural Science Foundation of China U2033217Natural Science Foundation of Sichuan Province 2022NSFSC1320STI 2030-Major Projects 2022ZD0208500
6 · The paper itself

Abstract

aimsMotor abnormalities have been identified as one common symptom in patients with generalized tonic-clonic seizures (GTCS) inspiring us to explore the disease in a motor execution condition, which might provide novel insight into the pathomechanism.

methodsResting-state and motor-task fMRI data were collected from 50 patients with GTCS, including 18 patients newly diagnosed without antiepileptic drugs (ND_GTCS) and 32 patients receiving antiepileptic drugs (AEDs_GTCS). Motor activation and its association with head motion and cerebral gradients were assessed. Whole-brain network connectivity across resting and motor states was further calculated and compared between groups.

resultsAll patients showed over-activation in the postcentral gyrus and the ND_GTCS showed decreased activation in putamen. Specifically, activation maps of ND_GTCS showed an abnormal correlation with head motion and cerebral gradient. Moreover, we detected altered functional network connectivity in patients within states and across resting and motor states by using repeated-measures analysis of variance. Patients did not show abnormal connectivity in the resting state, while distributed abnormal connectivity in the motor-task state. Decreased across-state network connectivity was also found in all patients.

conclusionConvergent findings suggested the over-response of activation and connection of the brain to motor execution in GTCS, providing new clues to uncover motor susceptibility underlying the disease.

Indexed as

BrainMagnetic Resonance ImagingRestSeizuresAdolescentAdultAnticonvulsantsBrain MappingFemaleHumansMaleMiddle AgedMotor ActivityNeural PathwaysYoung AdultAnticonvulsantsactivationfMRIgeneralized tonic–clonic seizuresmotor‐task statenetwork connectivityresting statewhite matter

Identifiers

PMID38644561
PMCPMC11033329
OpenAlexW4395006791

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.