Evidence map›Paper›PMID 38644548›Full record

ArticleJournal of biomedical materials research. Part A2024

Injectable bioactive poly(propylene fumarate) and polycaprolactone based click chemistry bone cement for spinal fusion in rabbits.

Xifeng Liu, Maria D Astudillo Potes, Vitalii Serdiuk, Babak Dashtdar, Areonna C Schreiber, Asghar Rezaei, A Lee Miller, Abdelrahman M Hamouda, Mahnoor Shafi, Benjamin D Elder and 1 more

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In one paragraph

Article in Journal of biomedical materials research. Part A, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xifeng LiuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-2684-6309
Maria D Astudillo PotesDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Vitalii SerdiukDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Babak DashtdarDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Areonna C SchreiberDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Asghar RezaeiDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
A Lee MillerDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Abdelrahman M HamoudaDepartment of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Mahnoor ShafiDepartment of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Benjamin D ElderDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Lichun LuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · US

Funding

Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment - MasterR01AR056212 · NIAMS · MAYO CLINIC ROCHESTER · PI Benjamin D Elder, Lichun Lu · 2008 to 2026
$6.2M
Injectable and Moldable Composite Bone Scaffolds for Spinal FusionR01AR075037 · NIAMS · MAYO CLINIC ROCHESTER · PI ELDER, BENJAMIN D, LU, LICHUN · 2019 to 2023
$2.5M
NIAMS NIH HHS R01 AR056212NIAMS NIH HHS R01 AR075037NIH HHS
6 · The paper itself

Abstract

Degenerative spinal pathology is a widespread medical issue, and spine fusion surgeries are frequently performed. In this study, we fabricated an injectable bioactive click chemistry polymer cement for use in spinal fusion and bone regrowth. Taking advantages of the bioorthogonal click reaction, this cement can be crosslinked by itself eliminating the addition of a toxic initiator or catalyst, nor any external energy sources like UV light or heat. Furthermore, nano-hydroxyapatite (nHA) and microspheres carrying recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human vascular endothelial growth factor (rhVEGF) were used to make the cement bioactive for vascular induction and osteointegration. After implantation into a rabbit posterolateral spinal fusion (PLF) model, the cement showed excellent induction of new bone formation and bridging bone, achieving results comparable to autograft control. This is largely due to the osteogenic properties of nano-hydroxyapatite (nHA) and the released rhBMP-2 and rhVEGF growth factors. Since the availability of autograft sources is limited in clinical settings, this injectable bioactive click chemistry cement may be a promising alternative for spine fusion applications in addressing various spinal conditions.

Indexed as

Bone CementsBone Morphogenetic Protein 2Click ChemistryFumaratesPolyestersPolypropylenesSpinal FusionVascular Endothelial Growth Factor AAnimalsBiocompatible MaterialsDurapatiteHumansInjectionsRabbitsRecombinant ProteinsTransforming Growth Factor betaBiocompatible MaterialsBone CementsBone Morphogenetic Protein 2DurapatiteFumaratespolycaprolactonePolyesterspoly(propylene fumarate)Polypropylenesrecombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor betaVascular Endothelial Growth Factor Abioorthogonal click chemistrybone cementinjectable polymersspine fusiontissue engineering

Identifiers

PMID38644548
PMCPMC11806930
OpenAlexW4395006764

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.