Evidence map›Paper›PMID 38644501›Full record

ArticleJournal of inflammation (London, England)2024

Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway.

Meng Chen, Jian Lv, Ningning Guo, Tuo Ji, Yu Fang, Zhihua Wang, Xianghu He

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Meng Chen *Department of Anesthesiology, Zhongnan Hospital of Wuhan University, 430071, Wuhan, Hubei, China.
Jian Lv *Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, 518057, Shenzhen, China.
Ningning GuoShenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, 518057, Shenzhen, China.
Tuo JiDepartment of Anesthesiology, Zhongnan Hospital of Wuhan University, 430071, Wuhan, Hubei, China.
Yu FangShenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, 518057, Shenzhen, China.
Zhihua WangShenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, 518057, Shenzhen, China. wangzhihua@fuwaisz.cn.
Xianghu HeDepartment of Anesthesiology, Zhongnan Hospital of Wuhan University, 430071, Wuhan, Hubei, China. hexh1220@aliyun.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNFu Wai Hospital · CNZhongnan Hospital of Wuhan University · CNWuhan University · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515012517Medical Research Project from Shenzhen Academy of Medical Sciences B2302026National Natural Science Foundation of China 82370392; 82070231Science, Technology and Innovation Commission of Shenzhen Municipality RCJC20210706091947009
6 · The paper itself

Abstract

backgroundInterplay between systemic inflammation and programmed cell death contributes to the pathogenesis of acute lung injury (ALI). cAMP-regulated transcriptional coactivator 1 (CRTC1) has been involved in the normal function of the pulmonary system, but its role in ALI remains unclear. METHODS AND

resultsWe generated a Crtc1 knockout (KO; Crtc1

conclusionsOur study demonstrates that CRTC1 contribute to the pathological processes of inflammation and apoptosis in sepsis-induced ALI, and provides mechanistic insights into the molecular function of CRTC1 in the lung. Targeting CRTC1 would be a promising strategy to treat sepsis-induced ALI in clinic.

Indexed as

Acute lung injuryApoptosisCrtc1InflammationSepsis

Identifiers

PMID38644501
PMCPMC11034098
OpenAlexW4395007491

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.