Evidence map›Paper›PMID 38644432›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Synthesis and preclinical evaluation of novel

G B Spoelstra, S N Blok, L Reali Nazario, L Noord, Y Fu, N A Simeth, F F A IJpma, M van Oosten, J M van Dijl, B L Feringa and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Radiolabeled Antimicrobials for Infection Imaging: A Scoping Review.International journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Mechanism Inversion in Visible Light-Induced Photoclick Reactions.Journal of the American Chemical Society · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

G B SpoelstraDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
S N BlokDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
L Reali NazarioDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
L NoordDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
Y FuStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, Groningen, 9747AG, The Netherlands.
N A SimethInstitute for Organic and Biomolecular Chemistry, Department of Chemistry, University of Göttingen, Tammannstraβe 2, 37077, Göttingen, Germany.
F F A IJpmaDepartment of Trauma Surgery, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
M van OostenDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
J M van DijlDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
B L FeringaStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, Groningen, 9747AG, The Netherlands.
W SzymanskiDepartment of Radiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands.
P H ElsingaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands. p.h.elsinga@umcg.nl.
University of Groningen · NLUniversity Medical Center Groningen · NLUniversity of Göttingen · DE

Funding

Stichting voor de Technische Wetenschappen 16895
6 · The paper itself

Abstract

introductionBacterial infections are a major problem in medicine, and the rapid and accurate detection of such infections is essential for optimal patient outcome. Bacterial infections can be diagnosed by nuclear imaging, but most currently available modalities are unable to discriminate infection from sterile inflammation. Bacteria-targeted positron emission tomography (PET) tracers have the potential to overcome this hurdle. In the present study, we compared three

methods[

results[

conclusionHere we present the synthesis and first evaluation of the vancomycin-based PET tracers [

Indexed as

Fluorine RadioisotopesPositron-Emission TomographyVancomycinAnimalsBacterial InfectionsChemistry Techniques, SyntheticMiceRadioactive TracersRadiochemistryRadiopharmaceuticalsTissue DistributionFluorine-18Fluorine RadioisotopesRadioactive TracersRadiopharmaceuticalsVancomycinBacterial infection imagingBiodistributionFluorine-18Gram-positivePositron emission tomographyVancomycin

Identifiers

PMID38644432
PMCPMC11224109
OpenAlexW4395007658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.