Evidence map›Paper›PMID 38644415›Full record

ArticleAnnals of hematology2024

Mendelian randomization of circulating proteome identifies IFN-γ as a druggable target in aplastic anemia.

Shanshan Qin, Yingxin Jiang, Yang Ou, Yanxia Zhan, Lili Ji, Pengcheng Xu, Xia Shao, Hao Chen, Tong Chen, Yunfeng Cheng

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
  3. [Causal relationship between autoimmune diseases and aplastic anemia: A Mendelian randomization study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shanshan Qin *Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yingxin Jiang *Centenary Institute, The University of Sydney, Sydney, NSW, 2050, Australia.
Yang OuDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yanxia ZhanDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Lili JiDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Pengcheng XuDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xia ShaoDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hao ChenDepartment of Thoracic Surgery, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, 200237, China.
Tong ChenDepartment of Hematology, Huashan Hospital, Fudan University, Shanghai, 200040, China. chentong@fudan.edu.cn.
Yunfeng ChengDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. yfcheng@fudan.edu.cn.ORCID http://orcid.org/0000-0002-9581-1134
Sun Yat-sen University · CNFudan University · CNThe University of Sydney · AU

Funding

Key Subject Construction Program of Shanghai Health Administrative Authority ZK2019B30National Natural Science Foundation of China 81870098National Natural Science Foundation of China 82370130Program of Shanghai Academic Research Leader 20XD1401000Shanghai Engineering Research Center of Tumor Multi-Target Gene Diagnosis 20DZ2254300
6 · The paper itself

Abstract

backgroundAplastic anemia (AA) is a kind of bone marrow failure (BMF) characterized by pancytopenia with hypoplasia/aplasia of bone marrow. Immunosuppressive therapy and bone marrow transplantation are effective methods to treat severe aplastic anemia. However, the efficacy is limited by complications and the availability of suitable donors. This study aimed to determine whether any circulating druggable protein levels may have causal effects on AA and provide potential novel drug targets for AA.

methodsGenetic variants strongly associated with circulating druggable protein levels to perform Mendelian randomization (MR) analyses were used. The effect of these druggable protein levels on AA risk was measured using the summary statistics from a large-scale proteomic genome-wide association study (GWAS) and FinnGen database ( https://www.finngen.fi/en/access_results ). Multivariable MR analyses were performed to statistically adjust for potential confounders, including platelet counts, reticulocyte counts, neutrophil counts, and proportions of hematopoietic stem cells.

resultsThe data showed that higher level of circulating IFN-γ levels was causally associated with AA susceptibility. The causal effects of circulating IFN-γ levels on the AA were broadly consistent, when adjusted for platelet counts, reticulocyte counts, neutrophil counts and proportions of hematopoietic stem cells.

conclusionsHigh levels of circulating IFN-γ levels might increase the risk of AA and might provide a potential novel target for AA.

Indexed as

Anemia, AplasticGenome-Wide Association StudyInterferon-gammaMendelian Randomization AnalysisProteomeFemaleHumansMaleIFNG protein, humanInterferon-gammaProteomeAplastic anemiaCytokineGenome-wide association study (GWAS)Mendelian randomization (MR)

Identifiers

PMID38644415
OpenAlexW4395008786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.