Evidence map›Paper›PMID 38644201›Full record

ReviewMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2024

So You Want to Image Myelin Using MRI: Magnetic Susceptibility Source Separation for Myelin Imaging.

Jongho Lee, Sooyeon Ji, Se-Hong Oh

Abstract readReview
In one paragraph

Review in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Vessel segmentation forMagnetic resonance in medicine · 2026
    Article
  4. Importance of RMagnetic resonance in medicine · 2026
    Article
  5. Review
  6. Article
  7. Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Advanced Techniques for MR Neuroimaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jongho LeeDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, Korea.ORCID http://orcid.org/0000-0002-9485-5434
Sooyeon JiDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, Korea.ORCID http://orcid.org/0000-0003-1644-6560
Se-Hong OhBiomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea.ORCID http://orcid.org/0000-0001-9771-8382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In MRI, researchers have long endeavored to effectively visualize myelin distribution in the brain, a pursuit with significant implications for both scientific research and clinical applications. Over time, various methods such as myelin water imaging, magnetization transfer imaging, and relaxometric imaging have been developed, each carrying distinct advantages and limitations. Recently, an innovative technique named as magnetic susceptibility source separation has emerged, introducing a novel surrogate biomarker for myelin in the form of a diamagnetic susceptibility map. This paper comprehensively reviews this cutting-edge method, providing the fundamental concepts of magnetic susceptibility, susceptibility imaging, and the validation of the diamagnetic susceptibility map as a myelin biomarker that indirectly measures myelin content. Additionally, the paper explores essential aspects of data acquisition and processing, offering practical insights for readers. A comparison with established myelin imaging methods is also presented, and both current and prospective clinical and scientific applications are discussed to provide a holistic understanding of the technique. This work aims to serve as a foundational resource for newcomers entering this dynamic and rapidly expanding field.

Indexed as

BrainMagnetic Resonance ImagingMyelin SheathHumansImage Processing, Computer-Assistedchi-separation or χ-separationmagnetic susceptibility source separationmyelin imagingmyelin water imagingquantitative susceptibility mapping

Identifiers

PMID38644201
PMCPMC11234950

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.