Evidence map›Paper›PMID 38643415›Full record

ArticleClinical chemistry and laboratory medicine2024

Confounding factors of the expression of mTBI biomarkers, S100B, GFAP and UCH-L1 in an aging population.

Emma Calluy, Charlotte Beaudart, Majed S Alokail, Nasser M Al-Daghri, Olivier Bruyère, Jean-Yves Reginster, Etienne Cavalier, Aurélie Ladang

Open access · hybridAbstract read
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In one paragraph

Article in Clinical chemistry and laboratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Interpreting p-tau217 on the ward: frailty and plasma biomarkers in acutely admitted older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Emma CalluyClinical Chemistry Department, CHU de Liège, University of Liège, Liège, Belgium.
Charlotte BeaudartWHO Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
Majed S AlokailProtein Research Chair, Biochemistry Department, 37850 College of Science, KSU , Riyadh, Kingdom of Saudi Arabia.
Nasser M Al-DaghriChair for Biomarkers of Chronic Diseases, Biochemistry Department, 37850 College of Science, KSU , Riyadh, Kingdom of Saudi Arabia.
Olivier BruyèreWHO Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
Jean-Yves ReginsterWHO Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.ORCID 0000-0001-6290-752X
Etienne CavalierClinical Chemistry Department, CHU de Liège, University of Liège, Liège, Belgium.ORCID 0000-0003-0947-2226
Aurélie LadangClinical Chemistry Department, CHU de Liège, University of Liège, Liège, Belgium.ORCID 0000-0002-5316-3108
University of Liège · BEUniversity of Namur · BE

Funding

clinical chemistry department and University of LiègeDistinguished Scientist Fellowship Program from the King Saud University.
6 · The paper itself

Abstract

objectivesTo evaluate some confounding factors that influence the concentrations of S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl-terminal hydrolase L-1 (UCH-L1) in older individuals. Indeed, recent guidelines have proposed the combined use of S100B and the "GFAP-UCH-L1" mTBI test to rule out mild traumatic brain injuries (mTBI). As older adults are the most at risk of mTBI, it is particularly important to understand the confounding factors of those mTBI rule-out biomarkers in aging population.

methodsThe protein S100B and the "GFAP and UCH-L1" mTBI test were measured using Liaison XL (Diasorin) and Alinity I (Abbott), respectively, in 330 and 341 individuals with non-suspected mTBI from the SarcoPhAge cohort.

resultsS100B, GFAP and UCH-L1 were all significantly correlated with renal function whereas alcohol consumption, Geriatric Depression Score (GDS), smoking habits and anticoagulant intake were not associated with any of these three biomarkers. Body mass index (BMI) and age were associated with GFAP and UCH-L1 expression while sex and mini-mental state examination (MMSE) were only associated with GFAP. According to the manufacturer's cut-offs for mTBI rule-out, only 5.5 % of participants were positive for S100B whereas 66.9 % were positive for the "GFAP-UCH-L1" mTBI test. All positive "GFAP-UCH-L1" mTBI tests were GFAP+/UCH-L1-. Among individuals with cystatin C>1.55 mg/L, 25 % were positive for S100B while 90 % were positive for the mTBI test.

conclusionsOur data show that confounding factors have different impacts on the positivity rate of the "GFAP-UCH-L1" mTBI test compared to S100B.

Indexed as

BiomarkersGlial Fibrillary Acidic ProteinS100 Calcium Binding Protein beta SubunitUbiquitin ThiolesteraseAgedAged, 80 and overAgingBrain ConcussionFemaleHumansMaleMiddle AgedBiomarkersGFAP protein, humanGlial Fibrillary Acidic ProteinS100B protein, humanS100 Calcium Binding Protein beta SubunitUbiquitin ThiolesteraseUCHL1 protein, humanblood-based biomarkersconfounding factorsmild traumatic brain injurynormally aging non-suspected casesspecificity

Identifiers

PMID38643415
OpenAlexW4394984234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.