Evidence map›Paper›PMID 38643323›Full record

ArticleMolecular biology reports2024

Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous H

Jiankun Cui, Xin Wang, Lingling Dong, Qinwen Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Epigenetics-targeted drugs: current paradigms and future challenges.Signal transduction and targeted therapy · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jiankun CuiCardiovascular Department, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, No.26 Heping Road, Harbin, Heilongjiang, 150040, China.
Xin WangDepartment of Chinese Medicine Treating Preventable Diseases, Dezhou Traditional Chinese Medicine Hospital, No. 1165 Tianqu East Road, Dezhou, 253000, China.
Lingling DongDepartment of Intensive Medicine, Dezhou Traditional Chinese Medicine Hospital, No. 1165 Tianqu East Road, Dezhou, 253000, China. donglingling1258@163.com.
Qinwen WangBeijing Garrison District Haidian Retired Cadres Twenty-Fifth, Beijing, 100039, China. 08198306@163.com.
First Affiliated Hospital of Heilongjiang University of Chinese Medicine · CNJining Traditional Chinese Medicine Hospital · CN

Funding

National Natural Science Foundation Project 82274238
6 · The paper itself

Abstract

backgroundOur previous research shows that Curcumin (CUR) attenuates myocardial ischemia-reperfusion injury (MIRI) by reducing intracellular total RNA m

methodsFor ischemia-reperfusion (IR), H9c2 cells were cultured for 6 h in serum-free low-glycemic (1 g/L) medium and a gas environment without oxygen, and then cultured for 6 h in high-glycemic (4.5 g/L) medium supplemented with 10% FBS and a 21% oxygen environment. The effects of different concentrations of CUR (5, 10, and 20 µM) treatments on signaling molecules in conventionally cultured and IR-treated H9c2 cells were examined.

resultsCUR treatment significantly up-regulated the H

conclusionCUR attenuates MIRI by regulating the expression of H

Indexed as

CurcuminHydrogen SulfideMyocardial Reperfusion InjuryAlpha-Ketoglutarate-Dependent Dioxygenase FTOHumansMethyltransferasesMitochondrial ProteinsNucleocytoplasmic Transport ProteinsOxygenRNAAlpha-Ketoglutarate-Dependent Dioxygenase FTOCurcuminETHE1 protein, humanFTO protein, humanHydrogen SulfideMethyltransferasesMETTL3 protein, humanMitochondrial ProteinsNucleocytoplasmic Transport ProteinsOxygenRNACurcuminCystathionine γ-lyaseH2Sm6AMyocardial ischemia-reperfusion injury

Identifiers

PMID38643323
OpenAlexW4394988175

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.