Evidence map›Paper›PMID 38643259›Full record

ArticleDrug delivery and translational research2025

Effect of PLGA raw materials on in vitro and in vivo performance of drug-loaded microspheres.

Desheng Liang, Jennifer Walker, Peter S Schwendeman, Aishwarya Chandrashekar, Rose Ackermann, Karl F Olsen, Moritz Beck-Broichsitter, Steven P Schwendeman

Abstract read
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. How PLGA Microspheres are Emerging as a Key Drug Delivery System.International journal of nanomedicine · 2026
    Review
  4. Article
  5. Article
  6. Platelet Membrane-Encapsulated Poly(lactic-International journal of pharmaceutics: X · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Desheng LiangDepartment of Pharmaceutical Sciences, The Biointerfaces Institute, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Jennifer WalkerDepartment of Pharmaceutical Sciences, The Biointerfaces Institute, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Peter S SchwendemanDepartment of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Ave., Ann Arbor, MI, 48109, USA.ORCID 0009-0001-7515-5889
Aishwarya ChandrashekarDepartment of Pharmaceutical Sciences, The Biointerfaces Institute, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.ORCID 0000-0001-5594-017X
Rose AckermannDepartment of Pharmaceutical Sciences, The Biointerfaces Institute, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Karl F OlsenDepartment of Pharmaceutical Sciences, The Biointerfaces Institute, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Moritz Beck-BroichsitterMilliporeSigma a Business of Merck Life Science KGaA, Frankfurter Strasse 250, D-64293, Darmstadt, Germany.
Steven P SchwendemanDepartment of Pharmaceutical Sciences, The Biointerfaces Institute, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA. schwende@med.umich.edu.ORCID 0000-0003-3470-624X
University of Michigan · USMerck (Germany) · DE

Funding

Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
NIGMS NIH HHS T32 GM145304NIH T32 GM 145304
6 · The paper itself

Abstract

Poly(lactide-co-glycolide) and poly(lactic-co-glycolic acids) (PLGAs) play a critical role in the development of commercial long-acting injectable microsphere formulations. However, very little information is available describing the impact of PLGA manufacturer and monomer distribution along the polymer chain (e.g., glycolic blockiness (R

Indexed as

Drug LiberationLeuprolideMicrospheresPolylactic Acid-Polyglycolic Acid CopolymerAnimalsDelayed-Action PreparationsDrug CarriersLactic AcidMalePolyglycolic AcidDelayed-Action PreparationsDrug CarriersLactic AcidLeuprolidePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerControlled releaseIn vitro and in vivo performanceMacromolecular propertiesMicrospheresPLGA raw material

Identifiers

PMID38643259
OpenAlexW4394987345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.