Evidence map›Paper›PMID 38643253›Full record

ArticleScientific reports2024

Interleukin-1α links peripheral Ca

Anne-Mary N Salib, Meredith J Crane, Sang Hun Lee, Brian J Wainger, Amanda M Jamieson, Diane Lipscombe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Channels (Austin, Tex.) · 2026
    Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Peripheral CaeNeuro · 2024
    Article
  5. Peripheral CabioRxiv : the preprint server for biology · 2024
    Article
  6. R and S enantiomers of CBD3063, a CaNeurobiology of pain (Cambridge, Mass.)
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Anne-Mary N SalibDepartment of Neuroscience, Carney Institute for Brain Science, Brown University, Providence, RI, 02912, USA.
Meredith J CraneDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912, USA.
Sang Hun LeeDepartment of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Brian J WaingerDepartment of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Amanda M JamiesonDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912, USA.
Diane LipscombeDepartment of Neuroscience, Carney Institute for Brain Science, Brown University, Providence, RI, 02912, USA. Diane_Lipscombe@brown.edu.
Allen Institute for Brain Science · USBrown University · USMassachusetts General Hospital · US

Funding

Voltage-Gated Calcium Channels in Nociceptors and MechanoreceptorsR01NS055251 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE · 2006 to 2025
$9.1M
Central role of Caspase-8 in control of host tolerance and resistance mechanisms in pulmonary macrophage populations during severe respiratory infectionsR01HL165259 · NHLBI · BROWN UNIVERSITY · PI Amanda M Jamieson · 2023 to 2026
$3.6M
Toward Precision Gene Therapy for Treatment of Severe Pain in Older IndividualsR21AG075419 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI WAINGER, BRIAN JASON · 2022 to 2023
$453k
NHLBI NIH HHS R01 HL165259NHLBI NIH HHS R01HL165259NIA NIH HHS 5R21AG075419NIA NIH HHS R21 AG075419NINDS NIH HHS NS055251NINDS NIH HHS R01 NS055251
6 · The paper itself

Abstract

Neurons have the unique capacity to adapt output in response to changes in their environment. Within seconds, sensory nerve endings can become hypersensitive to stimuli in response to potentially damaging events. The underlying behavioral response is well studied, but several of the key signaling molecules that mediate sensory hypersensitivity remain unknown. We previously discovered that peripheral voltage-gated Ca

Indexed as

Hot TemperatureInterleukin-1alphaAnimalsCalcium Channels, N-TypeCapsaicinMiceSensory Receptor CellsSkinCacna1b protein, mouseCalcium Channels, N-TypeCapsaicinIl1a protein, mouseInterleukin-1alpha

Identifiers

PMID38643253
PMCPMC11032389
OpenAlexW4394978023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.