Evidence map›Paper›PMID 38643200›Full record

ArticleNature communications2024

Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic.

Estefany Rios-Guzman, Lacy M Simons, Taylor J Dean, Francesca Agnes, Anna Pawlowski, Arghavan Alisoltanidehkordi, Hannah H Nam, Michael G Ison, Egon A Ozer, Ramon Lorenzo-Redondo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
27.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Burden of Respiratory Syncytial Virus Among Older Adults With an Acute Respiratory Infection: A Prospective Study in Six European Countries.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Observational
  8. Long-term Clinical Outcomes After Hospitalization for Acute Respiratory Illness Due to Respiratory Syncytial Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  9. Article
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  11. Article
  12. Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Estefany Rios-GuzmanDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0002-1399-7546
Lacy M SimonsDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0003-4041-6775
Taylor J DeanDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Francesca AgnesDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Anna PawlowskiNorthwestern Medicine Enterprise Data Warehouse, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0002-9047-6437
Arghavan AlisoltanidehkordiDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Hannah H NamDepartment of Infectious Diseases, University of California - Irvine, Orange, CA, 92868, USA.
Michael G IsonDivision of Microbiology and Infectious Diseases (DMID), National Institute of Health, Rockville, MD, 20852, USA.
Egon A OzerDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0002-7131-3691
Ramon Lorenzo-RedondoDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0002-5462-9483
Judd F HultquistDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. judd.hultquist@northwestern.edu.ORCID http://orcid.org/0000-0001-6424-4280
Northwestern University · USUniversity of California, Irvine · US

Funding

Targeting Viroporins and Coronavirus M ProteinU19AI171110 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$103.4M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2018 to 2026
$24.7M
TRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6M
NCATS NIH HHS UL1 TR001422NIAID NIH HHS T32 AI007476NIAID NIH HHS U19 AI135964NIAID NIH HHS U19 AI171110
6 · The paper itself

Abstract

Respiratory Syncytial Virus (RSV) is a leading cause of acute respiratory tract infection, with the greatest impact on infants, immunocompromised individuals, and older adults. RSV prevalence decreased substantially in the United States (US) following the implementation of COVID-19-related non-pharmaceutical interventions but later rebounded with abnormal seasonality. The biological and epidemiological factors underlying this altered behavior remain poorly defined. In this retrospective cohort study from 2009 to 2023 in Chicago, Illinois, US, we examined RSV epidemiology, clinical severity, and genetic diversity. We found that changes in RSV diagnostic platforms drove increased detections in outpatient settings post-2020 and that hospitalized adults infected with RSV-A were at higher risk of intensive care admission than those with RSV-B. While population structures of RSV-A remained unchanged, RSV-B exhibited a genetic shift into geographically distinct clusters. Mutations in the antigenic regions of the fusion protein suggest convergent evolution with potential implications for vaccine and therapeutic development.

Indexed as

COVID-19Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsAgedHumansInfantPandemicsRetrospective StudiesUnited States

Identifiers

PMID38643200
PMCPMC11032338
OpenAlexW4394987871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.