Evidence map›Paper›PMID 38643127›Full record

ArticleBMC veterinary research2024

Lactic acid bacteria reduce bacterial diarrhea in rabbits via enhancing immune function and restoring intestinal microbiota homeostasis.

Huimin Li, Chaoliang Leng, Nan Chen, Qinchao Ding, Yizhao Yuan, Yilei Zheng, Ge Zhu, Chen Chen, Lichang Xu, Jiangbing Shuai and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Dietary probiotic supplementation withAnimal biotechnology · 2025
    Article
  7. Article
  8. MixedFrontiers in microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Huimin Li *College of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Chaoliang Leng *Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology in Funiu Mountain, Nanyang Normal University, 473061, Nanyang, PR China.
Nan ChenCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Qinchao DingCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Yizhao YuanCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Yilei ZhengCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Ge ZhuCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Chen ChenCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Lichang XuCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Jiangbing ShuaiZhejiang Academy of Science & Technology for Inspection & Quarantine, 310016, Hangzhou, PR China.
Qinting JiangZhejiang Academy of Science & Technology for Inspection & Quarantine, 310016, Hangzhou, PR China.
Daxi RenCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
Huanan WangCollege of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China. hnwang@zju.edu.cn.
Zhejiang University · CNNanyang Normal University · CN

Funding

Fundamental Research Funds for the Central Universities 2022-KYY-517101-0005Key R&D Program Projects in Zhejiang Province, P. R. China 2021C02060, 2023C02037 and 2019C02091Science Fund for Distinguished Young Scholars of Zhejiang Province LR20H260001
6 · The paper itself

Abstract

backgroundNumerous previous reports have demonstrated the efficacy of Lactic acid bacteria (LAB) in promoting growth and preventing disease in animals. In this study, Enterococcus faecium ZJUIDS-R1 and Ligilactobaciiius animalis ZJUIDS-R2 were isolated from the feces of healthy rabbits, and both strains showed good probiotic properties in vitro. Two strains (10

resultsOur data showed that Enterococcus faecium ZJUIDS-R1 and Ligilactobaciiius animalis ZJUIDS-R2 interventions reduced the incidence of diarrhea and systemic inflammatory response, alleviated intestinal damage and increased antibody levels in animals. In addition, Enterococcus faecium ZJUIDS-R1 restored the flora abundance of Ruminococcaceae1. Ligilactobaciiius animalis ZJUIDS-R2 up-regulated the flora abundance of Adlercreutzia and Candidatus Saccharimonas. Both down-regulated the flora abundance of Shuttleworthia and Barnesiella to restore intestinal flora balance, thereby increasing intestinal short-chain fatty acid content.

conclusionsThese findings suggest that Enterococcus faecium ZJUIDS-R1 and Ligilactobaciiius animalis ZJUIDS-R2 were able to improve intestinal immunity, produce organic acids and regulate the balance of intestinal flora to enhance disease resistance and alleviate diarrhea-related diseases in weanling rabbits.

Indexed as

Bacterial InfectionsEnterococcus faeciumGastrointestinal MicrobiomeLactobacillalesProbioticsAnimalsDiarrheaImmunityRabbitsEnterococcus faeciumImmune functionIntestinal floraLABLigilactobaciiius Animalis

Identifiers

PMID38643127
PMCPMC11031951
OpenAlexW4394979789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.