Evidence map›Paper›PMID 38642938›Full record

ArticleJournal for immunotherapy of cancer2024

Dysregulation of CD4

Jun Yan He, Yang-Joon Kim, Elvira Mennillo, Iulia Rusu, Jared Bain, Arjun A Rao, Christopher Andersen, Karen Law, Hai Yang, Jessica Tsui and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The roles and heterogeneity of CD8International journal of molecular medicine · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Dysregulation of CD4Journal for immunotherapy of cancer · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 1 country.

Jun Yan HeDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Yang-Joon KimChan Zuckerberg Biohub, San Francisco, California, USA.
Elvira MennilloDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Iulia RusuDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jared BainDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Arjun A RaoCoLabs, University of California, San Francisco, San Francisco, California, USA.
Christopher AndersenCoLabs, University of California, San Francisco, San Francisco, California, USA.
Karen LawDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Hai YangDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Jessica TsuiCoLabs, University of California, San Francisco, San Francisco, California, USA.
Alan ShenCoLabs, University of California, San Francisco, San Francisco, California, USA.
Brittany DavidsonCoLabs, University of California, San Francisco, San Francisco, California, USA.
Divyashree KushnoorCoLabs, University of California, San Francisco, San Francisco, California, USA.
Yimin ShiDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Frances FanDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Alexander CheungDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-2115-6966
Li ZhangDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Lawrence FongDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Alexis J CombesDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Angela O PiscoChan Zuckerberg Biohub, San Francisco, California, USA.
Michael G Kattah *Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA David.Oh@ucsf.edu michael.kattah@ucsf.edu.
David Y Oh *Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA David.Oh@ucsf.edu michael.kattah@ucsf.edu.ORCID 0000-0002-3310-0994
University of California, San Francisco · USChan Zuckerberg Initiative (United States) · US

Funding

Determinants of response to cancer immunotherapyR35CA253175 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lawrence Fong · 2021 to 2026
$5.8M
Identification of circulating and tissue-specific autoimmune responses in checkpoint inhibitor-induced immune-related adverse eventsK08AI139375 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OH, DAVID YOONSUK · 2019 to 2023
$995k
Mechanisms of intestinal epithelial injury in intestinal inflammationK08DK123202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATTAH, MICHAEL GEORGE · 2020 to 2024
$860k
NCI NIH HHS R35 CA253175NIAID NIH HHS K08 AI139375NIDDK NIH HHS K08 DK123202
6 · The paper itself

Abstract

backgroundColitis caused by checkpoint inhibitors (CPI) is frequent and is treated with empiric steroids, but CPI colitis mechanisms in steroid-experienced or refractory disease are unclear.

methodsUsing colon biopsies and blood from predominantly steroid-experienced CPI colitis patients, we performed multiplexed single-cell transcriptomics and proteomics to nominate contributing populations.

resultsCPI colitis biopsies showed enrichment of CD4

conclusionsThese findings nominate CD4

Indexed as

CD8-Positive T-LymphocytesColitisCD4-Positive T-LymphocytesEndothelial CellsHumansSteroidsStromal CellsTumor Necrosis Factor InhibitorsSteroidsTumor Necrosis Factor InhibitorsColitisImmune Checkpoint InhibitorImmune related adverse event - irAEMemory

Identifiers

PMID38642938
PMCPMC11033653
OpenAlexW4394991673

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.