Evidence map›Paper›PMID 38642910›Full record

ArticleAmerican journal of hypertension2024

Factor VIII and Incident Hypertension in Black and White Adults: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort.

Eric Stoutenburg, Sarah Sherman, Maria Bravo, Virginia Howard, Debora Kamin Mukaz, Mary Cushman, Neil A Zakai, Suzanne Judd, Timothy B Plante

Open access · greenAbstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Eric StoutenburgDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Sarah ShermanDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Maria BravoDepartment of Biochemistry, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Virginia HowardDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Debora Kamin MukazDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Neil A ZakaiDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Suzanne JuddDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Timothy B PlanteDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.ORCID 0000-0001-9992-9597
University of Vermont · USUniversity of Alabama at Birmingham · USTulane University · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundNearly half of all Americans have hypertension, and Black adults experience a disproportionate burden. Hypercoagulability may relate to hypertension risk, and higher levels of factor VIII increase thrombosis risk. Black adults have higher factor VIII and more hypertension than other groups. Whether higher factor VIII associates with incident hypertension is unknown.

methodsThe Biomarkers as Mediators of Racial Disparities in Risk Factors (BioMedioR) study measured certain biomarkers in a sex-race stratified sample of 4,400 REGARDS participants who attended both visits. We included BioMedioR participants, excluding those with prevalent hypertension, missing factor VIII level, or covariates of interest. Modified Poisson regression estimated risk ratios (RR) for incident hypertension by higher log-transformed factor VIII level per SD (SD of log-transformed factor VIII, 0.33). Weighting was applied to take advantage of REGARDS sampling design.

resultsAmong the 1,814 participants included (55% female, 24% Black race), the median follow-up was 9.5 years and 35% (2,146/6,138) developed hypertension. Black participants had a higher median (IQR) factor VIII level (105.6%; 87.1%-126.9%) than White participants (95.6%; 79.8%-115.9%; P < 0.001). The age- and sex-adjusted Black-White hypertension RR was 1.45 (95% CI 1.28, 1.63). Higher factor VIII was not associated with more hypertension (final model RR 1.01; 95% CI 0.94, 1.07).

conclusionsIn a prospective study of Black and White adults without prevalent hypertension, factor VIII was not associated with greater hypertension risk.

Indexed as

Factor VIIIHealth Status DisparitiesHypertensionAgedBiomarkersBlack or African AmericanBlood PressureFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsStrokeBiomarkersF8 protein, humanFactor VIIIblood pressurefactor VIIIhypertensioninflammationracial disparities

Identifiers

PMID38642910
PMCPMC13016670
OpenAlexW4394979891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.