Evidence map›Paper›PMID 38642862›Full record

ArticleBehavioural brain research2024

Alpha event-related decreases during encoding in adults with ADHD - An investigation of sustained attention and working memory processes.

René Freichel, Nicolas Zink, Fang Yu Chang, Juan Diego Vera, Holly Truong, Giorgia Michelini, Sandra K Loo, Agatha Lenartowicz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

René FreichelDepartment of Psychology, University of Amsterdam, The Netherlands. Electronic address: r.freichel@uva.nl.
Nicolas ZinkSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, United States.
Fang Yu ChangSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, United States.
Juan Diego VeraSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, United States; Department of Psychology, University of California Los Angeles, Los Angeles, United States.
Holly TruongSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
Giorgia MicheliniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States; Department of Biological & Experimental Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
Sandra K LooSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
Agatha LenartowiczSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
University of California, Los Angeles · USUniversity of Southern California · USUniversity of Amsterdam · NL

Funding

Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigationR01MH116268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LENARTOWICZ, AGATHA, LOO, SANDRA K · 2019 to 2023
$3.5M
Efficacy of External Trigeminal Nerve Stimulation for Treatment of ADHDR01MH126041 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, SANDRA K, MCGOUGH, JAMES JOHN · 2022 to 2025
$2.9M
Understanding the neurocognitive mechanisms of alpha-band brain oscillations using concurrent EEG-fMRI recordingsR01MH128475 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Agatha Lenartowicz · 2022 to 2026
$2.6M
Genetics of EEG Patterns in ADHDR01NS054124 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, SANDRA K · 2006 to 2010
$1.7M
The neurophysiological basis of interindividual variability (IIV) in ADHDR01MH130731 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LENARTOWICZ, AGATHA · 2023 to 2025
$833k
NIMH NIH HHS R01 MH116268NIMH NIH HHS R01 MH126041NIMH NIH HHS R01 MH128475NIMH NIH HHS R01 MH130731NINDS NIH HHS R01 NS054124
6 · The paper itself

Abstract

backgroundExecutive functioning deficits are central to established neuropsychological models of ADHD. Oscillatory activity, particularly the alpha rhythm (8-12 Hz) has been associated with cognitive impairments in ADHD. However, most studies to date examined such neural mechanisms underlying executive dysfunction in children and adolescents with ADHD, raising the question of whether and to what extent those ADHD-related working memory impairments are still present in adults. To this end, the current study aimed to investigate the role of alpha event-related decreases (ERD) during working memory processes in adults with and without ADHD.

methodsWe collected electroencephalographic (EEG) data from 85 adults with a lifetime diagnosis of ADHD and 105 controls (aged 32-64), while they performed a continuous performance (CPT) and a spatial delayed response working memory task (SDRT). Time-frequency and independent component analysis (ICA) was used to identify alpha (8-12 Hz) clusters to examine group and condition effects during the temporal profile of sustained attention and working memory processes (encoding, maintenance, retrieval), loads (low and high) and trial type (go and nogo).

resultsIndividuals with ADHD exhibited higher reaction time-variability in SDRT, and slower response times in SDRT and CPT, despite no differences in task accuracy. Although working memory load was associated with stronger alpha ERD in both tasks and both groups (ADHD, controls), we found no consistent evidence for attenuated alpha ERD in adults with ADHD, failing to replicate effects reported in children. In contrast, when looking at the whole sample, the correlations of alpha power during encoding with inattention and hyperactivity-impulsivity symptoms were significant, replicating prior findings in children with ADHD, but suggesting an alternate source for these effects in adults.

conclusionsOur results corroborate the robustness of alpha as a marker of visual attention and suggest that occipital alpha ERD normalizes in adulthood, but with unique contributions of centro-occipital alpha ERD, suggesting a secondary source. This implies that deviations in processes other than previously reported visuospatial cortex engagement may account for the persistent symptoms and cognitive deficits in adults with a history of ADHD.

Indexed as

Alpha RhythmAttentionAttention Deficit Disorder with HyperactivityMemory, Short-TermAdultElectroencephalographyExecutive FunctionFemaleHumansMaleMiddle AgedNeuropsychological TestsPsychomotor PerformanceReaction Time

Identifiers

PMID38642862
PMCPMC11687179
OpenAlexW4394958710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.