Evidence map›Paper›PMID 38642817›Full record

ArticleChemico-biological interactions2024

Mitomycin C and its analog trigger cytotoxicity in MCF-7 and K562 cancer cells through the regulation of RAS and MAPK/ERK pathways.

Owen Zacarias, Cristina C Clement, Shu-Yuan Cheng, Melissa Rosas, Christina Gonzalez, Marion Peter, Peter Coopman, Elise Champeil

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemico-biological interactions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Owen ZacariasDepartment of Sciences, John Jay College of Criminal Justice, The City University of New York, New York, NY, 10019, USA.
Cristina C ClementRadiation Oncology Department, Weill Cornell Medicine, New York, New York, 10065, USA. Electronic address: ccc4002@med.cornell.edu.
Shu-Yuan ChengDepartment of Sciences, John Jay College of Criminal Justice, The City University of New York, New York, NY, 10019, USA; Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA. Electronic address: shcheng@jjay.cuny.edu.
Melissa RosasDepartment of Sciences, John Jay College of Criminal Justice, The City University of New York, New York, NY, 10019, USA.
Christina GonzalezDepartment of Sciences, John Jay College of Criminal Justice, The City University of New York, New York, NY, 10019, USA.
Marion PeterIRCM, University Montpellier, ICM, INSERM, CNRS, Campus Val d'Aurelle, 208 avenue des apothicaires, 34298, Montpellier, Cédex 5, France.
Peter CoopmanIRCM, University Montpellier, ICM, INSERM, CNRS, Campus Val d'Aurelle, 208 avenue des apothicaires, 34298, Montpellier, Cédex 5, France.
Elise ChampeilDepartment of Sciences, John Jay College of Criminal Justice, The City University of New York, New York, NY, 10019, USA; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA. Electronic address: echampeil@jjay.cuny.edu.
City University of New York · USCentre National de la Recherche Scientifique · FRThe Graduate Center, CUNY · USCornell University · US

Funding

Role of p21 signaling pathway in response to MC & DMC DNA Interstrand CrosslinksSC3GM105460 · NIGMS · JOHN JAY COLLEGE OF CRIMINAL JUSTICE · PI CHAMPEIL, ELISE · 2014 to 2022
$1.2M
Identification of critical cellular pathways triggered by mitomycins interstrand crosslinksR16GM149514 · NIGMS · JOHN JAY COLLEGE OF CRIMINAL JUSTICE · PI Elise Champeil · 2023 to 2026
$643k
NIGMS NIH HHS R16 GM149514NIGMS NIH HHS SC3 GM105460
6 · The paper itself

Abstract

Mitomycin C (MC) is an anti-cancer drug which functions by forming interstrand crosslinks (ICLs) between opposing DNA strands. MC analog, 10-decarbamoyl mitomycin C (DMC), unlike MC, has stronger cytotoxic effects on cancer cells with TP53 mutation. We previously demonstrated that MC/DMC could activate p21

Indexed as

MAP Kinase Signaling SystemMitomycinras ProteinsHumansK562 CellsMCF-7 CellsTumor Suppressor Protein p53Mitomycinras ProteinsTumor Suppressor Protein p5310-Decarbamoyl mitomycin CInterstrand crosslinksMitomycin CProteomic profilingRAS pathway

Identifiers

PMID38642817
PMCPMC11102841
OpenAlexW4394936194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.