ArticleNeuron2024
Repeated stress triggers seeking of a starvation-like state in anxiety-prone female mice.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Xiangshao granules regulate the dopaminergic synapse pathway and improve menopausal anxiety in peri- and postmenopausal Chinese women: A multi-center, double-blind, randomized controlled trial.Acta pharmaceutica Sinica. B · 2026Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Dietary advanced glycation products combined with chronic restraint stress induced anxiety-like and depression-like behaviors in male mice.NPJ science of food · 2026Article
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- Examining the biological causes of eating disorders to inform treatment strategies.Nature reviews. Neuroscience · 2025Review
- Stress drives seeking of starvation.Nature reviews. Neuroscience · 2024Article
- What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research.Neuroscience applied · 2024Review
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.Molecular metabolism · 2023Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.bioRxiv : the preprint server for biology · 2023Article
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8 authors at 1 institution in 1 country.
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Abstract
Elevated anxiety often precedes anorexia nervosa and persists after weight restoration. Patients with anorexia nervosa often describe self-starvation as pleasant, potentially because food restriction can be anxiolytic. Here, we tested whether repeated stress can cause animals to prefer a starvation-like state. We developed a virtual reality place preference paradigm in which head-fixed mice can voluntarily seek a starvation-like state induced by optogenetic stimulation of hypothalamic agouti-related peptide (AgRP) neurons. Prior to stress exposure, males but not females showed a mild aversion to AgRP stimulation. Strikingly, following multiple days of stress, a subset of females developed a strong preference for AgRP stimulation that was predicted by high baseline anxiety. Such stress-induced changes in preference were reflected in changes in facial expressions during AgRP stimulation. Our study suggests that stress may cause females predisposed to anxiety to seek a starvation state and provides a powerful experimental framework for investigating the underlying neural mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.