Evidence map›Paper›PMID 38642547›Full record

ArticleClinical and experimental immunology2024

Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery.

Mohammad Ali, Stephanie Longet, Isabel Neale, Patpong Rongkard, Forhad Uddin Hassan Chowdhury, Jennifer Hill, Anthony Brown, Stephen Laidlaw, Tom Tipton, Ashraful Hoque and 24 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 9 institutions in 4 countries.

Mohammad AliPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-0170-7182
Stephanie LongetWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Isabel NealePeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Patpong RongkardPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Forhad Uddin Hassan ChowdhuryDepartment of Internal Medicine, Dhaka Medical College, Dhaka, Bangladesh.
Jennifer HillPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Anthony BrownPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Stephen LaidlawWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Tom TiptonWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Ashraful HoqueDepartment of Transfusion Medicine, Sheikh Hasina National Burn & Plastics Surgery Institute, Dhaka, Bangladesh.
Nazia HassanDepartment of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Carl-Philipp HacksteinPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Sandra AdelePeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Hossain Delowar AktherPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Priyanka AbrahamPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Shrebash PaulDepartment of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Md Matiur RahmanDepartment of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Md Masum AlamDepartment of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Shamima ParvinDepartment of Biochemistry and Molecular Biology, Mugda Medical College, Dhaka, Bangladesh.
Forhadul Hoque MollahDepartment of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Md Mozammel HoqueDepartment of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Shona C MooreTropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK.
Subrata K BiswasDepartment of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Lance TurtleTropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK.
Thushan I de SilvaDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Ane OgbePeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
John FraterPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-7163-7277
Eleanor BarnesPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Adriana TomicNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.
Miles W CarrollWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Paul KlenermanPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-4307-9161
Barbara KronsteinerPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Fazle Rabbi ChowdhuryMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Susanna J DunachiePeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Bangladesh Medical University · BDMahidol University · THUniversity of Oxford · GBCentre for Human Genetics · GBUniversity of Liverpool · GBBoston University · USComilla Medical College · BDUniversity of Connecticut · USUniversity of Sheffield · GB

Funding

Bangladesh Medical Research CouncilBSMMU Research BSMMU/2021/5567EU's Horizon2020 Marie Sklodowska-Curie Fellowship 796636Medical Research Council MR/X009297/1NIHR Global Research Professorship NIHR300791Wellcome TrustWellcome Trust 110058/Z/15/ZWellcome Trust Intermediate Clinical Fellowship
6 · The paper itself

Abstract

objectiveObesity and type 2 diabetes (DM) are risk factors for severe coronavirus disease 2019 (COVID-19) outcomes, which disproportionately affect South Asian populations. This study aims to investigate the humoral and cellular immune responses to SARS-CoV-2 in adult COVID-19 survivors with overweight/obesity (Ov/Ob, BMI ≥ 23 kg/m2) and DM in Bangladesh.

methodsIn this cross-sectional study, SARS-CoV-2-specific antibody and T-cell responses were investigated in 63 healthy and 75 PCR-confirmed COVID-19 recovered individuals in Bangladesh, during the pre-vaccination first wave of the COVID-19 pandemic in 2020.

resultsIn COVID-19 survivors, SARS-CoV-2 infection induced robust antibody and T-cell responses, which correlated with disease severity. After adjusting for age, sex, DM status, disease severity, and time since onset of symptoms, Ov/Ob was associated with decreased neutralizing antibody titers, and increased SARS-CoV-2 spike-specific IFN-γ response along with increased proliferation and IL-2 production by CD8 + T cells. In contrast, DM was not associated with SARS-CoV-2-specific antibody and T-cell responses after adjustment for obesity and other confounders.

conclusionOv/Ob is associated with lower neutralizing antibody levels and higher T-cell responses to SARS-CoV-2 post-COVID-19 recovery, while antibody or T-cell responses remain unaltered in DM.

Indexed as

Antibodies, NeutralizingAntibodies, ViralCOVID-19Diabetes Mellitus, Type 2ObesitySARS-CoV-2AdultBangladeshCD8-Positive T-LymphocytesCross-Sectional StudiesFemaleHumansImmunity, CellularMaleMiddle AgedT-LymphocytesAntibodies, NeutralizingAntibodies, ViralantibodyCOVID-19diabetes mellitusobesityT cell

Identifiers

PMID38642547
PMCPMC11404124
OpenAlexW4394975130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.