Evidence map›Paper›PMID 38642306›Full record

ArticleJournal of endocrinological investigation2024

CD20 + T lymphocytes in isolated Hashimoto's thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study.

Ilaria Stramazzo, Giorgio Mangino, Silvia Capriello, Giovanna Romeo, Silvia Martina Ferrari, Poupak Fallahi, Maria Flavia Bagaglini, Marco Centanni, Camilla Virili

Open access · hybridAbstract read
In one paragraph

Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ilaria StramazzoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Giorgio ManginoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Silvia CaprielloDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Giovanna RomeoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Silvia Martina FerrariDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Poupak FallahiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Maria Flavia BagagliniDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Marco CentanniDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy. marco.centanni@uniroma1.it.ORCID http://orcid.org/0000-0003-0661-1649
Camilla ViriliDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Sapienza University of Rome · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD20

methodsThe study group encompasses 65 HT patients: 23 presenting in isolated form (IT) and 42 with an associated non-endocrine autoimmune disorder [16 with chronic atrophic gastritis (CAG), 15 with nonsegmental vitiligo (VIT), and 11 with celiac disease (CD)]. Twenty healthy donors act as control group (HD). Chronic use of interfering drugs, severe or chronic disorders, and pregnancy and lactation were used as exclusion criteria. Whole blood samples (100 µl) were stained with fluorescent-labeled antibodies (anti-CD45, anti-CD3, anti-CD19, anti-CD16, anti-CD56, anti-CD4, anti-CD8, anti-CD20). Red blood cells were then lysed by adding 1 ml of hypotonic buffer, and samples were acquired on a Flow Cytometer.

resultsCD3

conclusionsThese preliminary findings indicate that CD8

Indexed as

Antigens, CD20Hashimoto DiseasePolyendocrinopathies, AutoimmuneAdultAgedCase-Control StudiesCeliac DiseaseFemaleGastritis, AtrophicHumansMaleMiddle AgedPilot ProjectsT-LymphocytesVitiligoAntigens, CD20CD20+ T lymphocytesHashimoto’s thyroiditisHypothyroidismPoly-autoimmunity

Identifiers

PMID38642306
PMCPMC11473566
OpenAlexW4394979954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.