ArticleEndocrine2024
Relationship between indices of insulin resistance and incident type 2 diabetes mellitus in Chinese adults.
Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Using the triglyceride-glucose index and derived indexes to forecast progression from pre-diabetes to diabetes: A 3-year follow-up study.World journal of diabetes · 2026Article
- A correlation analysis between TyG-derived indices and diabetes mellitus: based on the NHANES database.Endocrine journal · 2026Article
- Association between the triglyceride-glucose-frailty index and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of the poverty-income ratio.Cardiovascular diabetology · 2026Article
- Triglyceride-glucose-Body Mass Index is linked to papillary thyroid carcinoma odds in China: a retrospective study.Frontiers in endocrinology · 2026Article
- Association between plasma magnesium levels and glycolipid metabolism in a southern Chinese population: a cross-sectional study in Shenzhen.Frontiers in endocrinology · 2026Article
- Investigating the prediction potential of cholesterol, high-density lipoprotein, and glucose index surpasses TyG, AIP, and METS-IR for type 2 diabetes: a longitudinal cohort study.Frontiers in endocrinology · 2026Article
- Combined with the insulin resistance index in assessing subclinical systolic function in newly diagnosed type 2 diabetes mellitus: an analysis based on automated functional imaging echocardiography.BMC endocrine disorders · 2025Article
- Evaluation of the diagnostic efficacy of different glycemic markers and insulin indices for diabetes mellitus in a general population.Annals of medicine · 2025Article
- Relationship Between Insulin Resistance Indicators and Type 2 Diabetes Mellitus in Romania.International journal of molecular sciences · 2025Article
- YKL-40 Level Is Associated with TyG-BMI-Estimated Insulin Resistance and Metabolic Syndrome in a Population Without Diabetes, Independent of Obesity.International journal of molecular sciences · 2025Article
- Relationship between the triglyceride glucose index and time in range: A cross-sectional study based on patients with type 2 diabetes mellitus.The Journal of international medical research · 2025Article
- Sex differences in associations of metabolic inflammation and insulin resistance with incident type 2 diabetes mellitus: a retrospective cohort of adults with annual health examinations.Lipids in health and disease · 2025Article
- Triglyceride-glucose body mass index and the risk of gestational diabetes mellitus: a population-based cohort study.Frontiers in nutrition · 2025Article
- Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression.Clinical interventions in aging · 2025Article
- Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInsulin resistance (IR) is a pivotal pathogenesis characteristic of type 2 diabetes mellitus (T2DM). The current study aimed to explore the association between triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-c), triglyceride-glucose (TyG), and triglyceride glucose-body mass index (TyG-BMI), and T2DM incidence.
methodsA total of 116,855 Chinese adults aged over 20 without diabetes were included. Multivariate Cox regression analysis and restricted cubic spine were utilized to investigate the association between IR indicators and T2DM. The T2DM risk across different quartiles of IR parameters was compared using Kaplan-Meier curves. The receiver operating characteristic analysis was used to investigate the predictive potential of each IR indicator for future T2DM.
resultsA total of 2685 participants developed T2DM during a median follow-up of 2.98 years. The adjusted hazard ratios (HR) of incident T2DM were 1.177, 2.766, and 1.1018 for TG/HDL-c, TyG, and TyG-BMI, respectively. There were significant increasing trends of T2DM across the quartiles of TG/HDL-c, TyG, and TyG-BMI. The HRs of new-onset T2DM in the highest quartiles versus the lowest quartile of TG/HDL-c, TyG, and TyG-BMI were 3.298, 8.402, and 8.468. RCS revealed the nonlinear relationship between IR and T2DM risk. The correlations between IR and T2DM were more pronounced in subjects aged <40. TyG-BMI had the highest predictive value for incident T2DM (AUC = 0.774), with a cut-off value of 213.289.
conclusionTG/HDL-c, TyG, and TyG-BMI index were all significantly positively associated with higher risk for future T2DM. Baseline TyG-BMI level had high predictive value for the identification of T2DM.
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