Evidence map›Paper›PMID 38642279›Full record

ArticleGlycoconjugate journal2024

Increasing outer membrane complexity: the case of the lipopolysaccharide lipid A from marine Cellulophaga pacifica.

Emanuela Andretta, Stefania De Chiara, Chiara Pagliuca, Roberta Cirella, Elena Scaglione, Martina Di Rosario, Maxim S Kokoulin, Olga I Nedashkovskaya, Alba Silipo, Paola Salvatore and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Glycoconjugate journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Emanuela Andretta *Department of Chemical Sciences, University of Naples Federico II, via Cinthia, 4, Naples, 80126, Italy.ORCID 0000-0002-4402-0914
Stefania De Chiara *Department of Chemical Sciences, University of Naples Federico II, via Cinthia, 4, Naples, 80126, Italy.
Chiara PagliucaDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 5, Naples, 80131, Italy.
Roberta CirellaDepartment of Chemical Sciences, University of Naples Federico II, via Cinthia, 4, Naples, 80126, Italy.
Elena ScaglioneDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 5, Naples, 80131, Italy.
Martina Di RosarioDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 5, Naples, 80131, Italy.
Maxim S KokoulinFar Eastern Branch, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, 159/2, Prospect 100 Let Vladivostoku, Vladivostok, 690022, Russia.
Olga I NedashkovskayaFar Eastern Branch, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, 159/2, Prospect 100 Let Vladivostoku, Vladivostok, 690022, Russia.
Alba SilipoDepartment of Chemical Sciences, University of Naples Federico II, via Cinthia, 4, Naples, 80126, Italy.ORCID 0000-0002-5394-6532
Paola SalvatoreDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 5, Naples, 80131, Italy.
Antonio MolinaroDepartment of Chemical Sciences, University of Naples Federico II, via Cinthia, 4, Naples, 80126, Italy.ORCID 0000-0002-3456-7369
Flaviana Di LorenzoDepartment of Chemical Sciences, University of Naples Federico II, via Cinthia, 4, Naples, 80126, Italy. flaviana.dilorenzo@unina.it.ORCID 0000-0003-4821-0114
University of Naples Federico II · ITPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative bacteria living in marine waters have evolved peculiar adaptation strategies to deal with the numerous stress conditions that characterize aquatic environments. Among the multiple mechanisms for efficient adaptation, these bacteria typically exhibit chemical modifications in the structure of the lipopolysaccharide (LPS), which is a fundamental component of their outer membrane. In particular, the glycolipid anchor to the membrane of marine bacteria LPSs, i.e. the lipid A, frequently shows unusual chemical structures, which are reflected in equally singular immunological properties with potential applications as immune adjuvants or anti-sepsis drugs. In this work, we determined the chemical structure of the lipid A from Cellulophaga pacifica KMM 3664

Indexed as

Lipid AAnimalsBacterial Outer MembraneLipopolysaccharidesMiceToll-Like Receptor 4Lipid ALipopolysaccharidesToll-Like Receptor 4CellulophagaInnate immunityLipid ALipopolysaccharideMALDI-TOF MSMarine bacteria

Identifiers

PMID38642279
PMCPMC11065906
OpenAlexW4394976506

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.