Evidence map›Paper›PMID 38642272›Full record

ReviewCurrent gastroenterology reports2024

The Role of the Gut Microbiome in Health and Disease in the Elderly.

Lea Ann Chen, Kaitlyn Boyle

Abstract readReview
In one paragraph

Review in Current gastroenterology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Journal of microbiology and biotechnology · 2025
    Article
  4. Review
  5. The blood-brain barrier: a help and a hindrance.Brain : a journal of neurology · 2025
    Review
  6. Review
  7. Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lea Ann ChenDivision of Gastroenterology and Hepatology, Department of Medicine, Rutgers, New Brunswick, NJ, USA. leaann.chen@rutgers.edu.
Kaitlyn BoyleRutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Funding

The Study of Families with Heritable Crohn's Disease to Support Rational Design of Microbiota-based TherapiesK23DK119544 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI CHEN, LEA A · 2020 to 2024
$1.1M
NIDDK NIH HHS K23 DK119544
6 · The paper itself

Abstract

purpose of reviewGrowing evidence supports the contribution of age in the composition and function of the gut microbiome, with specific findings associated with health in old age and longevity. RECENT

findingsCurrent studies have associated certain microbiota, such as Butyricimonas, Akkermansia, and Odoribacter, with healthy aging and the ability to survive into extreme old age. Furthermore, emerging clinical and pre-clinical research have shown promising mechanisms for restoring a healthy microbiome in elderly populations through various interventions such as fecal microbiota transplant (FMT), dietary interventions, and exercise programs. Despite several conceptually exciting interventional studies, the field of microbiome research in the elderly remains limited. Specifically, large longitudinal studies are needed to better understand causative relationships between the microbiome and healthy aging. Additionally, individualized approaches to microbiome interventions based on patients' co-morbidities and the underlying functional capacity of their microbiomes are needed to achieve optimal results.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeAgedAgingHealthy AgingHumansAged, 80 and olderAgingFrailnessGeriatricMicrobiotaProbiotics

Identifiers

PMID38642272
PMCPMC11282161

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.