Evidence map›Paper›PMID 38642254›Full record

ReviewWorld journal of microbiology & biotechnology2024

Bacterial extracellular vesicles: biotechnological perspective for enhanced productivity.

Laura M Muñoz-Echeverri, Santiago Benavides-López, Otto Geiger, Mauricio A Trujillo-Roldán, Norma A Valdez-Cruz

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of microbiology & biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  6. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  7. Frontiers in microbiology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Bacterial Extracellular Vesicles (BEVs) Derived FromInternational journal of biomaterials · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laura M Muñoz-EcheverriDepartamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México AP. 70228, Ciudad de México, C.P. 04510, México.
Santiago Benavides-LópezDepartamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México AP. 70228, Ciudad de México, C.P. 04510, México.
Otto GeigerCentro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Av. Universidad s/n, Cuernavaca, Morelos, CP 62210, México.
Mauricio A Trujillo-RoldánDepartamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México AP. 70228, Ciudad de México, C.P. 04510, México.
Norma A Valdez-CruzDepartamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México AP. 70228, Ciudad de México, C.P. 04510, México. adrivaldez1@gmail.com.
Universidad Nacional Autónoma de México · MXUniversidad Autónoma de Baja California · MX

Funding

Consejo Nacional de Ciencia y Tecnología CF-2023-I-1248Consejo Nacional de Ciencia y Tecnología CF-2023-I-1549Consejo Nacional de Ciencia y Tecnología CVU 1102921Consejo Nacional de Ciencia y Tecnología CVU 1102922Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México IN-211422Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México IV-201220
6 · The paper itself

Abstract

Bacterial extracellular vesicles (BEVs) are non-replicative nanostructures released by Gram-negative and Gram-positive bacteria as a survival mechanism and inter- and intraspecific communication mechanism. Due to BEVs physical, biochemical, and biofunctional characteristics, there is interest in producing and using them in developing new therapeutics, vaccines, or delivery systems. However, BEV release is typically low, limiting their application. Here, we provide a biotechnological perspective to enhance BEV production, highlighting current strategies. The strategies include the production of hypervesiculating strains through gene modification, bacteria culture under stress conditions, and artificial vesicles production. We discussed the effect of these production strategies on BEVs types, morphology, composition, and activity. Furthermore, we summarized general aspects of BEV biogenesis, functional capabilities, and applications, framing their current importance and the need to produce them in abundance. This review will expand the knowledge about the range of strategies associated with BEV bioprocesses to increase their productivity and extend their application possibilities.

Indexed as

Extracellular VesiclesGram-Positive BacteriaBiotechnologyArtificial bacterial vesiclesBacterial extracellular vesicles (BEVs)Hypervesiculation strainsVesiculation cellular response to stress

Identifiers

PMID38642254
PMCPMC11032300
OpenAlexW4394979221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.