Evidence map›Paper›PMID 38642200›Full record

ArticleMolecular biology reports2024

Discovery of YS-1 as a cell line of gastric inflammatory cancer-associated fibroblasts.

Satoe Numakura, Masahiro Kato, Hiroshi Uozaki

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Satoe NumakuraDepartment of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. s.numakura@med.teikyo-u.ac.jp.
Masahiro KatoDepartment of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Hiroshi UozakiDepartment of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Teikyo University · JP

Funding

the Japan Society for the Promotion of Science (JSPS) KAKENHI 20K16203
6 · The paper itself

Abstract

backgroundInflammatory cancer-associated fibroblasts (iCAFs) was first identified by co-culture of pancreatic stellate cells and tumor organoids. The key feature of iCAFs is IL-6 METHODS AND

resultsHGF or YS-1 were co-cultured with MKN7 (a gastric adenocarcinoma cell line) in Matrigel. IL-6 protein levels in the culture supernatant were measured by ELISA. The increased production of IL-6 was not observed in any of the combinations. Instead, the supernatant of YS-1 exhibited the higher levels of IL-6. YS-1 showed IL-6

conclusionsYS-1 is a stable cell line of gastric iCAFs. This discovery will promote further research on iCAFs for many researchers.

Indexed as

AdenocarcinomaCancer-Associated FibroblastsStomach NeoplasmsCell Line, TumorFibroblastsHedgehog ProteinsHumansInterleukin-6RNA, MessengerHedgehog ProteinsInterleukin-6RNA, MessengerCell lineGastric cancerInflammatory cancer associated fibroblasts (iCAFs)Interleukin-6 (IL-6)Leukemia inhibitory factor (LIF)

Identifiers

PMID38642200
OpenAlexW4394982227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.