Evidence map›Paper›PMID 38642092›Full record

ArticleAbdominal radiology (New York)2024

Multiparametric magnetic resonance imaging of the liver and spleen in Gaucher disease.

Daniella Braz Parente, Fernanda Chagas Monteiro de Melo Malta, Renata de Souza Cravo, Ronir Raggio Luiz, Vivian Rotman, Renata Mello Perez, Rosana Souza Rodrigues

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Article in Abdominal radiology (New York), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daniella Braz ParenteD'Or Institute for Research and Education, Rua Diniz Cordeiro, 30, 3º Andar. Botafogo., Rio de Janeiro, RJ, CEP 22281-100, Brazil. daniella.parente@gmail.com.ORCID 0000-0003-0031-5785
Fernanda Chagas Monteiro de Melo MaltaD'Or Institute for Research and Education, Rua Diniz Cordeiro, 30, 3º Andar. Botafogo., Rio de Janeiro, RJ, CEP 22281-100, Brazil.
Renata de Souza CravoArthur de Siqueira Cavalcanti State Institute of Hematology: Hospital Hemorio, R. Frei Caneca, 8. Centro., Rio de Janeiro, RJ, CEP 20211-030, Brazil.
Ronir Raggio LuizInstituto de Estudos Em Saúde Coletiva, Federal University of Rio de Janeiro, Cidade Universitária, Ilha Do Fundão, Rio de Janeiro, CEP 21941-592, Brazil.
Vivian RotmanFederal University of Rio de Janeiro, Cidade Universitária, Av. Professor Rodolpho Paulo Rocco 255. Ilha Do Fundão., Rio de Janeiro, RJ, CEP 21941-913, Brazil.
Renata Mello PerezD'Or Institute for Research and Education, Rua Diniz Cordeiro, 30, 3º Andar. Botafogo., Rio de Janeiro, RJ, CEP 22281-100, Brazil.
Rosana Souza RodriguesD'Or Institute for Research and Education, Rua Diniz Cordeiro, 30, 3º Andar. Botafogo., Rio de Janeiro, RJ, CEP 22281-100, Brazil.
Universidade Federal do Rio de Janeiro · BRD’Or Institute for Research and Education · BRHemorio · BR

Funding

STUDIES OF RETINITIS PIGMENTOSA AND ALLIED DISEASESU01EY002014 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BERSON, ELIOT L · 1988 to 1989
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STUDIES OF RETINITIS PIGMENTOSA AND ALLIED DISEASESU10EY002014 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BERSON, ELIOT L · 1990 to 1993
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Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E_32/2014 - Apoio à realização de pesquisas clínicas e translacionais no RJ - FAPERJ/IDOR - 2014Instituto D'Or de Pesquisa e Ensino E_32/2014 - Apoio à realização de pesquisas clínicas e translacionais no RJ - FAPERJ/IDOR - 2014
6 · The paper itself

Abstract

purposeTo assess liver and spleen characteristics of a population with Gaucher disease (GD) using multiparametric MRI and MR elastography (MRE) for evaluation of diffuse liver and spleen disease, which includes liver fat fraction, liver and spleen volume and iron deposition, and liver and spleen stiffness correlated with DS3 Severity Scoring System for Gaucher disease (GD-DS3).

methodsWe prospectively evaluated 41 patients with type 1 Gaucher disease using a 3.0 T MRI and MRE between January 2019 and February 2020. Clinical, laboratory, and imaging data was collected. Mann-Whitney, Kruskal-Wallis, and Spearman's correlation were applied to evaluate liver and spleen MRI and MRE, clinical and laboratory variables, and GD-DS3. ERT and SRT treatment groups were compared.

resultsHepatomegaly was seen in 15% and splenomegaly in 42% of the population. Moderate and strong and correlations were found between liver and spleen iron overload (rho = 0.537; p = 0.002); between liver and spleen volume (rho = 0.692, p < 0.001) and between liver and spleen stiffness (rho = 0.453, p = 0.006). Moderate correlations were found between liver stiffness and GD-DS3 (rho = 0.559; p < 0.001) and between splenic volume and GD-DS3 (rho = 0.524; p = 0.001).

conclusionThe prevalence of hepatosplenomegaly, liver fibrosis, and liver iron overload in treated patients with GD is low, which may be related to the beneficial effect of treatment. Liver MRE and splenic volume correlate with severity score and may be biomarkers of disease severity.

Indexed as

Elasticity Imaging TechniquesGaucher DiseaseLiverMultiparametric Magnetic Resonance ImagingSpleenAdolescentAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesSeverity of Illness IndexSplenomegalyYoung AdultElasticity imaging techniquesGaucher diseaseHepatomegalyMagnetic resonance imagingSplenomegaly

Identifiers

PMID38642092
OpenAlexW4394978522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.