Evidence map›Paper›PMID 38642085›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Serum inflammatory markers as prognostic marker for nasopharyngeal carcinoma with liver metastasis: a multi-center retrospective study.

Hossein Saboorifar, Yasamin Zafarani, Golsa Gholampour, Arman Roghani, Feng Qiu, Dideir Dequaniter, Qiao Yu

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 3 countries.

Hossein SaboorifarDepartment of Head and Neck Surgery, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID http://orcid.org/0009-0006-2831-3967
Yasamin ZafaraniDepartment of Head and Neck Surgery, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.ORCID http://orcid.org/0000-0002-6374-0845
Golsa GholampourDepartment of Head and Neck Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Arman RoghaniDepartment of Head and Neck Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
Feng QiuDepartment of Radiation Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, China.
Dideir DequaniterMedicine Faculty, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Qiao YuOtorhinolaryngology and Maxillofacial Department, First Affiliated Hospital of Nanchang University, Nanchang, China. qiao.yuu1989@gmail.com.ORCID http://orcid.org/0009-0002-6054-7879
Fujian Medical University · CNHamedan University of Medical Sciences · IRIsfahan University of Medical Sciences · IRNanchang University · CNQazvin University of Medical Sciences · IRTehran University of Medical Sciences · IRUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis retrospective study investigated the prognostic value of serum inflammatory markers in nasopharyngeal carcinoma (NPC) patients, focusing on their association with overall survival (OS) and liver metastasis-free survival (LMFS).

methodsThe study included 314 NPC patients treated between 2010 and 2020. Clinical characteristics, treatment methods, and serum inflammatory markers were assessed. Patients were categorized into two groups of with and without liver metastasis. Univariate and multivariate Cox regression and Kaplan-Meier survival analyses were performed to investigate the prognostic value of serum inflammatory markers in NPC patients with and without liver metastasis.

resultsIn the whole cohort, univariate Cox regression analysis singled out tumor necrosis factor-α (TNF-α) (HR = 1.57, 95% CI 1.44-4.90, p = 0.004) and neutrophil-to-lymphocyte ratio (NLR) (HR = 2.13, 95% CI 1.33-3.99, p = 0.009), which were significantly associated with poorer OS. In patients with liver metastasis, TNF-α and NLR could not independently predict OS. However, high TNF-α levels were independently associated with worse OS in patients without liver metastasis (HR (95% CI) = 2.75 (1.67-8.68), p < 0.001). High NLR levels could independently predict poor OS in both groups with (HR (95% CI) = 1.94 (1.77-6.38), p = 0.010) and without liver metastasis (HR (95% CI) = 1.58 (1.19-7.54), p = 0.009). Ultimately, TNF-α and NLR could not significantly predict LMFS.

conclusionThis study highlights the prognostic significance of TNF-α and NLR in NPC patients, especially in those with liver metastasis. These inflammatory markers could serve as valuable indicators for assessing the prognosis of NPC patients. Further research is warranted to validate their clinical utility and explore potential therapeutic implications.

Indexed as

Biomarkers, TumorLiver NeoplasmsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsAdultAgedFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeutrophilsPrognosisRetrospective StudiesTumor Necrosis Factor-alphaBiomarkers, TumorTumor Necrosis Factor-alphaNasopharyngeal carcinomaNLROverall survivalSerum inflammatory markersTNF-α

Identifiers

PMID38642085
OpenAlexW4394978775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.