Evidence map›Paper›PMID 38642028›Full record

ArticleAutism : the international journal of research and practice2024

Probing heterogeneity to identify individualized treatment approaches in autism: Specific clusters of executive function challenges link to distinct co-occurring mental health problems.

Cara E Pugliese, Rebecca Handsman, Xiaozhen You, Laura Gutermuth Anthony, Chandan Vaidya, Lauren Kenworthy

Open access · greenAbstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Executive function challenges persist into young adulthood and predict mental health outcomes in autism.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Cara E PuglieseChildren's National Hospital, USA.ORCID 0000-0001-8449-6602
Rebecca HandsmanChildren's National Hospital, USA.
Xiaozhen YouChildren's National Hospital, USA.
Laura Gutermuth AnthonyChildren's Hospital Colorado, USA.
Chandan VaidyaGeorgetown University, USA.
Lauren KenworthyChildren's National Hospital, USA.
Children's National · USChildren's Hospital Colorado · USGeorgetown University · US

Funding

The Cognitive Neuroscience of Autism Spectrum DisordersZIAMH002920 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MARTIN, ALEX · 2009 to 2025
$14.6M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Postdoctoral Training in Developmental Disabilities ResearchT32HD046388 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2006 to 2016
$1.5M
Behavioral and Neural Outcomes of a New Executive Function Treatment for Transition-Age Youth with ASDK23MH110612 · NIMH · CHILDREN'S RESEARCH INSTITUTE · PI PUGLIESE, CARA · 2016 to 2019
$616k
Intramural NIH HHS ZIA MH002920NICHD NIH HHS T32 HD046388NICHD NIH HHS U54 HD090257NIMH NIH HHS K23 MH110612
6 · The paper itself

Abstract

lay abstractMany autistic people struggle with mental health problems like anxiety, depression, inattention, and aggression, which can be challenging to treat. Executive function challenges, which impact many autistic individuals, may serve as a risk factor for mental health problems or make treating mental health conditions more difficult. While some people respond well to medication or therapy, others do not. This study tried to understand if there are different subgroups of autistic young people who may have similar patterns of executive function strengths and challenges-like flexibility, planning, self-monitoring, and emotion regulation. Then, we investigated whether executive function subgroups were related to mental health problems in autistic youth. We found three different types of executive function subgroups in autistic youth, each with different patterns of mental health problems. This helps us identify specific profiles of executive function strengths and challenges that may be helpful with identifying personalized supports, services, and treatment strategies for mental health conditions.

Indexed as

Executive FunctionMental DisordersAdolescentAutism Spectrum DisorderAutistic DisorderChildEmotional RegulationFemaleHumansMalePrecision MedicineYoung Adultanxietyautism spectrum disordersdepressionexecutive functionpsychiatric comorbidity

Identifiers

PMID38642028
PMCPMC11490586
OpenAlexW4394970949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.