Evidence map›Paper›PMID 38641829›Full record

SynthesisItalian journal of pediatrics2024

Kidney and urogenital abnormalities in Down syndrome: a meta-analysis.

Caterina Maria Rossetti, Giacomo D Simonetti, Mario G Bianchetti, Sebastiano A G Lava, Giorgio Treglia, Carlo Agostoni, Gregorio P Milani, J Peter de Winter

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Italian journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Caterina Maria RossettiPediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Giacomo D SimonettiPediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Mario G BianchettiPediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. mario.bianchetti@usi.ch.
Sebastiano A G LavaPediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Giorgio TregliaFaculty of Biomedical Sciences, Università della Svizzera Italiana, via Buffi 13, Lugano, Switzerland.
Carlo AgostoniPediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Gregorio P MilaniPediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
J Peter de WinterDepartment of Development and Regeneration, Leuven, Belgium.
Università della Svizzera italiana · CHFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituto Pediatrico della Svizzera ItalianaSpaarne Gasthuis · NLUniversity Hospital of Lausanne · CHUniversity of Milan · IT

Funding

Ministero della Salute Ricerca Corrente
6 · The paper itself

Abstract

backgroundReviews on Down syndrome do not or only marginally address the issue of kidney and urogenital tract abnormalities, and lower urinary tract dysfunctions. Hence, we performed a meta-analysis of the literature. 

methodsA literature search was undertaken in the Library of Medicine, Web of Science and Excerpta Medica. The search algorithm combined various keywords: (Down syndrome OR trisomy 21 OR mongolism) AND (kidney OR urinary tract OR bladder) AND (malformation OR dysfunction OR anomaly OR abnormality OR size). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was used.

resultsEight case-control studies were retained for the final analysis. Three studies addressed the prevalence of kidney and urogenital tract abnormalities: an increased pooled relative risk of 5.49 (95%-CI: 1.78-16.93) was observed in Down syndrome. Penile malformations, obstructive malformations (including urethral valves), dilated urinary tract system, and kidney hypodysplasia were especially common. Three reports addressed the prevalence of lower urinary tract dysfunction: an increased pooled relative risk of 2.95 (95%-CI: 1.15-7.56) was observed. Finally, an autoptic study and an ultrasound study disclosed a reduced kidney size in Down syndrome.

conclusionsThis meta-analysis indicates that abnormalities of the kidney and urogenital tract, lower urinary tract dysfunctions, and a reduced kidney size present with an increased frequency in individuals with Down syndrome.

Indexed as

Down SyndromeUrinary TractUrogenital AbnormalitiesHumansKidneyDown syndromeDysfunction of the urinary bladderKidney sizeMeta-analysisUrogenital abnormalities

Identifiers

PMID38641829
PMCPMC11031854
OpenAlexW4394978551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.