Evidence map›Paper›PMID 38641760›Full record

ArticleApoptosis : an international journal on programmed cell death2024

IRG1/Itaconate inhibits proliferation and promotes apoptosis of CD69

Pei Zhou, Kaixiong Tao, Liwu Zeng, Xinyu Zeng, Yaqi Wan, Gengchen Xie, Xinghua Liu, Peng Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026
    Review
  2. Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pei Zhou *Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Kaixiong Tao *Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Liwu ZengDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Xinyu ZengDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Yaqi WanDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Gengchen XieDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Xinghua LiuDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Peng ZhangDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China. zhangpeng_xt@hust.edu.cn.
Union Hospital · CNHuazhong University of Science and Technology · CN

Funding

Kaixiong Tao 81874184Peng Zhang 82102299
6 · The paper itself

Abstract

To investigate the protective role of immune response gene 1 (IRG1) and exogenous itaconate in autoimmune hepatitis (AIH) and elucidate the underlying mechanisms. Wild-type and IRG1

Indexed as

Antigens, Differentiation, T-LymphocyteApoptosisCD8-Positive T-LymphocytesCell ProliferationHepatitis, AutoimmuneIntegrin alpha ChainsJanus Kinase 3STAT3 Transcription FactorTumor Suppressor Protein p53AnimalsAntigens, CDCD69 AntigensDisease Models, AnimalLectins, C-TypeLiverMemory T Cellsalpha E integrinsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensIntegrin alpha ChainsJak3 protein, mouseJanus Kinase 3Lectins, C-TypeStat3 protein, mouseSTAT3 Transcription FactorTrp53 protein, mouseTumor Suppressor Protein p53Autoimmune hepatitisIRG1/itaconateJAK3/STAT3/P53Tissue-resident memory T cells

Identifiers

PMID38641760
OpenAlexW4394951466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.