ArticleAnnals of intensive care2024
Combined cardiac, lung, and diaphragm ultrasound for predicting weaning failure during spontaneous breathing trial.
Article in Annals of intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Predictive value of diaphragmatic ultrasound for weaning outcomes in mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis.Critical care (London, England) · 2026Pooled it
- Midaxillary-to-midclavicular diaphragmatic mobility ratio predicts weaning success in invasive mechanical ventilation: an observational cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Phenotype-based modeling of postoperative ventilatory liberation failure: A dynamic mechanistic framework for precision perioperative medicine.Journal of anesthesia and translational medicine · 2026Review
- Integrated comprehensive assessment for predicting weaning success in difficult-to-wean critically ill patients: the WEAN-US study.Critical care (London, England) · 2026Observational
- Bedside Diaphragm and Lung Ultrasound for Predicting Liberation from Mechanical Ventilation: A Systematic Review with Clinical Synthesis.Journal of clinical medicine · 2026Review
- Modified Venous Excess Ultrasound (mVExUS) in the Prediction of Ventilator Weaning Failure: a Cohort Study.POCUS journal · 2026Article
- Weaning failure from mechanical ventilation: a scoping review of the utility of ultrasonography in the weaning process.British journal of anaesthesia · 2025Article
- Use of ultrasonic left ventricular pressure-strain loops to predict weaning failure in critically ill patients: a pilot study.Quantitative imaging in medicine and surgery · 2025Article
- Weaning management in a patient with heart dysfunction: a case report.Frontiers in physiology · 2025Article
- Clinical prediction scores predicting weaning failure from invasive mechanical ventilation: Role and limitations.World journal of critical care medicine · 2024Review
- Predictors of weaning failure in ventilated intensive care patients: a systematic evidence map.Critical care (London, England) · 2024Review
- Weaning Failure in Elderly Patients: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- MUltiparametric Score for Ventilation Discontinuation in Intensive Care Patients: A Protocol for an Observational Study.Methods and protocols · 2024Article
- Ultrasound predictors of extubation outcomes in pediatric cardiac surgery: A prospective evaluation of lung, diaphragmatic, and cardiac ultrasound.Annals of pediatric cardiologyArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWeaning from invasive mechanical ventilation (MV) is a complex and challenging process that involves multiple pathophysiological mechanisms. A combined ultrasound evaluation of the heart, lungs, and diaphragm during the weaning phase can help to identify risk factors and underlying mechanisms for weaning failure. This study aimed to investigate the accuracy of lung ultrasound (LUS), transthoracic echocardiography (TTE), and diaphragm ultrasound for predicting weaning failure in critically ill patients.
methodsPatients undergoing invasive MV for > 48 h and who were readied for their first spontaneous breathing trial (SBT) were studied. Patients were scheduled for a 2-h SBT using low-level pressure support ventilation. LUS and TTE were performed prospectively before and 30 min after starting the SBT, and diaphragm ultrasound was only performed 30 min after starting the SBT. Weaning failure was defined as failure of SBT, re-intubation, or non-invasive ventilation within 48 h.
resultsFifty-one patients were included, of whom 15 experienced weaning failure. During the SBT, the global, anterior, and antero-lateral LUS scores were higher in the failed group than in the successful group. Receiver operating characteristic curve analysis showed that the areas under the curves for diaphragm thickening fraction (DTF) and global and antero-lateral LUS scores during the SBT to predict weaning failure were 0.678, 0.719, and 0.721, respectively. There was no correlation between the LUS scores and the average E/e' ratio during the SBT. Multivariate analysis identified antero-lateral LUS score > 7 and DTF < 31% during the SBT as independent predictors of weaning failure.
conclusionLUS and diaphragm ultrasound can help to predict weaning failure in patients undergoing an SBT with low-level pressure support. An antero-lateral LUS score > 7 and DTF < 31% during the SBT were associated with weaning failure.
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