Evidence map›Paper›PMID 38641668›Full record

ArticleCommunications biology2024

Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren's disease.

Myung-Chul Kim, Umasankar De, Nicholas Borcherding, Lei Wang, Joon Paek, Indraneel Bhattacharyya, Qing Yu, Ryan Kolb, Theodore Drashansky, Akaluck Thatayatikom and 2 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Myung-Chul KimDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Umasankar DeDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, 32610, USA.ORCID 0000-0003-4478-791X
Nicholas BorcherdingDepartment of Pathology & Immunology, Washington University School of Medicine in St. Louis, St Louis, MO, 63110, USA.
Lei WangDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Joon PaekCenter for Orphaned Autoimmune Disorders, University of Florida College of Dentistry, Gainesville, FL, 32610, USA.
Indraneel BhattacharyyaCenter for Orphaned Autoimmune Disorders, University of Florida College of Dentistry, Gainesville, FL, 32610, USA.
Qing YuThe Forsyth Institute, Cambridge, MA, 02142, USA.
Ryan KolbDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Theodore DrashanskyCellularity, Inc. 170 Park Ave, Florham Park, NJ, 07932, USA.
Akaluck Thatayatikom *AdventHealth Medical Group, Orlando, FL, 32643, USA. akaluck1@hotmail.com.
Weizhou Zhang *Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, 32610, USA. zhangw@ufl.edu.ORCID 0000-0002-8236-0346
Seunghee Cha *Center for Orphaned Autoimmune Disorders, University of Florida College of Dentistry, Gainesville, FL, 32610, USA. scha@dental.ufl.edu.ORCID 0000-0003-3772-1832
University of Florida Health · USUniversity of Florida · USWashington University in St. Louis · USAdventHealth Orlando · USCellular Biomedicine Group (United States) · US

Funding

Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasisR01CA260239 · NCI · UNIVERSITY OF FLORIDA · PI ZHANG, WEIZHOU · 2021 to 2025
$2.5M
Regulation and Function of Interleukin-7 in Primary Sjogrens SyndromeR01DE023838 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI YU, QING · 2014 to 2018
$2.4M
PKR sensing of mitochondrial dsRNA in childhood Sjogrens diseaseR01DE032707 · NIDCR · UNIVERSITY OF FLORIDA · PI SEUNGHEE CHA · 2023 to 2026
$2.4M
Proteolysis targeting chimera against nuclear receptor NR4A1 for melanoma therapyR01CA290792 · NCI · UNIVERSITY OF FLORIDA · PI Keiran Smalley, Weizhou Zhang · 2024 to 2026
$2.0M
Exploring novel therapeutic strategies for combinatory therapy to treat renal clear cell carcinomasR01CA269661 · NCI · UNIVERSITY OF FLORIDA · PI Weizhou Zhang · 2023 to 2026
$1.9M
CD177 suppresses breast-cancer development by inhibiting beta-cateninR01CA203834 · NCI · UNIVERSITY OF IOWA · PI ZHANG, WEIZHOU · 2016 to 2020
$1.7M
Mechanisms and Therapeutic Modulation of T Cell Autoimmune Responses in Sjogren's SyndromeR56DE023838 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI CHA, SEUNGHEE, YU, QING · 2020 to 2020
$532k
Cytoplasmic mitochondrial dsRNA in pediatric Sjogren's syndromeR21AR079693 · NIAMS · UNIVERSITY OF FLORIDA · PI CHA, SEUNGHEE · 2021 to 2021
$369k
NCI NIH HHS R01 CA203834NCI NIH HHS R01 CA260239NCI NIH HHS R01 CA269661NCI NIH HHS R01 CA290792NIAMS NIH HHS R21 AR079693NIDCR NIH HHS R01 DE023838NIDCR NIH HHS R01 DE032707NIDCR NIH HHS R56 DE023838
6 · The paper itself

Abstract

Childhood Sjögren's disease represents critically unmet medical needs due to a complete lack of immunological and molecular characterizations. This study presents key immune cell subsets and their interactions in the periphery in childhood Sjögren's disease. Here we show that single-cell RNA sequencing identifies the subsets of IFN gene-enriched monocytes, CD4

Indexed as

Sjogren's SyndromeAdultChildChild, PreschoolGene Expression ProfilingHumansKiller Cells, NaturalT-Lymphocytes, RegulatoryTranscriptome

Identifiers

PMID38641668
PMCPMC11031574
OpenAlexW4394951153

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.