Evidence map›Paper›PMID 38641579›Full record

ArticleBMC public health2024

Associations between Life's Essential 8 and abdominal aortic calcification among US Adults: a cross-sectional study.

Quanjun Liu, Hong Xiang, Shuhua Chen, Jie Ouyang, Huiqin Liu, Jing Zhang, Yanfei Chai, Peng Gao, Xiao Zhang, Jianing Fan and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Quanjun Liu *Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China.
Hong Xiang *Center for Experimental Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Shuhua ChenDepartment of Biochemistry, School of Life Sciences of Central, South University, Changsha, China.
Jie OuyangHealth Management Center, The Third Xiangya Hospital of Central South University, Changsha, China.
Huiqin LiuHealth Management Center, The Third Xiangya Hospital of Central South University, Changsha, China.
Jing ZhangHealth Management Center, The Third Xiangya Hospital of Central South University, Changsha, China.
Yanfei ChaiHealth Management Center, The Third Xiangya Hospital of Central South University, Changsha, China.
Peng GaoHealth Management Center, The Third Xiangya Hospital of Central South University, Changsha, China.
Xiao ZhangDepartment of Biochemistry, School of Life Sciences of Central, South University, Changsha, China.
Jianing FanHealth Management Center, The Third Xiangya Hospital of Central South University, Changsha, China.
Xinru ZhengHealth Management Center, The Third Xiangya Hospital of Central South University, Changsha, China.
Hongwei LuHealth Management Center, The Third Xiangya Hospital of Central South University, Changsha, China. hongweilu@csu.edu.cn.
Third Xiangya Hospital · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular health (CVH) and abdominal aortic calcification (AAC) are closely linked to cardiovascular disease (CVD) and related mortality. However, the relationship between CVH metrics via Life's Essential 8 (LE8) and AAC remains unexplored.

methodsThe study analyzed data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) cohort, which included adults aged 40 or above. The research used the LE8 algorithm to evaluate CVH. Semi-quantitative AAC-24 scoring techniques were employed to assess AAC, categorized into no calcification, mild to moderate calcification, and severe calcification.

resultsThe primary analysis involved 2,478 participants. Following adjustments for multiple factors, the LE8 score exhibited a significant association with ACC risk (Mild-moderate ACC: 0.87, 95% CI: 0.81,0.93; Severe ACC: 0.77, 95% CI: 0.69,0.87, all P < 0.001), indicating an almost linear dose-response relationship. Compared to the low CVH group, the moderate CVH group showed lower odds ratios (OR) for mild-moderate and severe calcification (OR = 0.78, 95% CI: 0.61-0.99, P = 0.041; OR = 0.68, 95% CI: 0.46-0.99, P = 0.047, respectively). Moreover, the high CVH group demonstrated even lower ORs for mild-moderate and severe calcification (OR = 0.46, 95% CI: 0.31, 0.69, P < 0.001; OR = 0.29, 95% CI: 0.14, 0.59, P = 0.001, respectively). Interactions were found between chronic kidney disease (CKD) condition, history of CVD, marital status and CVH metrics to ACC. Participants without CKD exhibited a more pronounced negative association between the CVH metric and both mild-moderate and severe ACC. Those lacking a history of CVD, and never married/widowed/divorced/separated showed a stronger negative association between the CVH metric and severe ACC.

conclusionsThe novel CVH metrics demonstrated an inverse correlation with the risk of AAC. These findings suggest that embracing improved CVH levels may assist in alleviating the burden of ACC.

Indexed as

Cardiovascular DiseasesRenal Insufficiency, ChronicAdultCross-Sectional StudiesHumansNutrition SurveysResearch DesignRisk FactorsUnited StatesAbdominal aortic calcificationCardiovascular diseaseCardiovascular healthLife’s Essential 8NHANES

Identifiers

PMID38641579
PMCPMC11031939
OpenAlexW4394942447

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.