ArticleProceedings of the National Academy of Sciences of the United States of America1985
Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 129 citations in OpenAlex.
- Intergenic bidirectional promoter and cooperative regulation of the IIx and IIb MHC genes in fast skeletal muscle.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.Journal of muscle research and cell motility · 2006Article
- Cluster characterisation and temporal expression of porcine sarcomeric myosin heavy chain genes.Journal of muscle research and cell motility · 2003Article
- Reversible Ca2+-induced fast-to-slow transition in primary skeletal muscle culture cells at the mRNA level.The Journal of physiology · 2000Article
- Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development.Journal of muscle research and cell motility · 2000Article
- The 5'-end of the porcine perinatal myosin heavy chain gene shows alternative splicing and is clustered with repeat elements.Journal of muscle research and cell motility · 2000Article
- Expression and localisation of annexin VII (synexin) isoforms in differentiating myoblasts.Journal of muscle research and cell motility · 1999Article
- Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Isolation and localization of the skeletal myosin heavy chain 2X gene on pig chromosome 12q1.4-q1.5.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Growth and muscle defects in mice lacking adult myosin heavy chain genes.The Journal of cell biology · 1997Article
- A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiation.The Journal of cell biology · 1997Article
- Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch.Journal of anatomy · 1997Article
- The inhibition of cultured myoblast differentiation by the simian virus 40 large T antigen occurs after myogenin expression and Rb up-regulation and is not exerted by transformation-competent cytoplasmic mutants.Journal of virology · 1995Article
- Cardiac alpha-myosin heavy chains differ in their induction of myocarditis. Identification of pathogenic epitopes.The Journal of clinical investigation · 1993Article
- Organization of the human skeletal myosin heavy chain gene cluster.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Mapping of the nu gene using congenic nude strains and in situ hybridization.The Journal of experimental medicine · 1992Article
- Four sarcomeric myosin heavy chain genes are expressed by human fetal skeletal muscle cells differentiating in culture.Gene expression · 1992Article
- Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198.Immunogenetics · 1992Article
- Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myosin heavy chain (MHC) genes are expressed as several distinct isoforms in a tissue- and stage-specific manner; three skeletal muscle MHC isoforms appear sequentially during development. We have isolated cDNA clones, identified by RNA blot hybridization and by nucleotide sequence determination as coding for portions of the embryonic (pMHC2.2), perinatal (pMHC16.2A), and alpha(V1) cardiac (pMHC141 and pMHC101) MHC isoforms. These four probes and the adult skeletal MHC probe (pMHC32) have been used on Southern blots of genomic DNA to detect restriction fragment length polymorphisms defining the alleles for these genes in mouse species Mus musculus and Mus spretus. In this way, we followed the segregation of skeletal and cardiac MHC genes in 42 offspring resulting from an interspecies backcross. We found that the embryonic, perinatal, and adult skeletal MHC genes are clustered on chromosome 11 near the locus nude, the skeletal and cardiac MHC genes do not cosegregate, and the alpha(V1) cardiac MHC gene is located on chromosome 14 close to Np-1. This result is in contrast to that for other contractile protein genes such as the alkali myosin light chain and the actin multigene families, which are dispersed in the genome.
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