Evidence map›Paper›PMID 38641410›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2024

The use of artificial intelligence to optimize medication alerts generated by clinical decision support systems: a scoping review.

Jetske Graafsma, Rachel M Murphy, Ewoudt M W van de Garde, Fatma Karapinar-Çarkit, Hieronymus J Derijks, Rien H L Hoge, Joanna E Klopotowska, Patricia M L A van den Bemt

Open access · hybridAbstract readScoping Review
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
28.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 40 citations in OpenAlex.

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  8. Transforming Human-AI Collaboration in Emergency Care: The Role of AI in Adaptive Support Across Diagnostic Reasoning Modes.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026
    Article
  9. Can Artificial Intelligence Improve Deprescribing in Older Adults?Geriatrics & gerontology international · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Jetske GraafsmaDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, 9713GZ, The Netherlands.ORCID 0009-0003-5275-1199
Rachel M MurphyDepartment of Medical Informatics Amsterdam UMC, University of Amsterdam, Amsterdam, 1000GG, The Netherlands.ORCID 0000-0002-2602-5658
Ewoudt M W van de GardeDepartment of Pharmacy, St Antonius Hospital, Utrecht, 3430AM, The Netherlands.
Fatma Karapinar-ÇarkitDepartment of Clinical Pharmacy and Toxicology, Maastricht University Medical Center, Maastricht, 6229HX, The Netherlands.
Hieronymus J DerijksDepartment of Pharmacy, Jeroen Bosch Hospital, Den Bosch, 5200ME, The Netherlands.
Rien H L HogeDepartment of Pharmacy, Wilhelmina Hospital, Assen, 9401RK, The Netherlands.
Joanna E KlopotowskaDepartment of Medical Informatics Amsterdam UMC, University of Amsterdam, Amsterdam, 1000GG, The Netherlands.
Patricia M L A van den BemtDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, 9713GZ, The Netherlands.
Amsterdam University Medical Centers · NLUniversity Medical Center Groningen · NLJeroen Bosch Ziekenhuis · NLMaastricht University · NLUtrecht University · NLWilhelmina Children's Hospital · NL

Funding

Dutch national Medicines Coordination CenterLandelijk Coördinatiecentrum Geneesmiddelen
6 · The paper itself

Abstract

objectiveCurrent Clinical Decision Support Systems (CDSSs) generate medication alerts that are of limited clinical value, causing alert fatigue. Artificial Intelligence (AI)-based methods may help in optimizing medication alerts. Therefore, we conducted a scoping review on the current state of the use of AI to optimize medication alerts in a hospital setting. Specifically, we aimed to identify the applied AI methods used together with their performance measures and main outcome measures. MATERIALS AND

methodsWe searched Medline, Embase, and Cochrane Library database on May 25, 2023 for studies of any quantitative design, in which the use of AI-based methods was investigated to optimize medication alerts generated by CDSSs in a hospital setting. The screening process was supported by ASReview software.

resultsOut of 5625 citations screened for eligibility, 10 studies were included. Three studies (30%) reported on both statistical performance and clinical outcomes. The most often reported performance measure was positive predictive value ranging from 9% to 100%. Regarding main outcome measures, alerts optimized using AI-based methods resulted in a decreased alert burden, increased identification of inappropriate or atypical prescriptions, and enabled prediction of user responses. In only 2 studies the AI-based alerts were implemented in hospital practice, and none of the studies conducted external validation. DISCUSSION AND

conclusionAI-based methods can be used to optimize medication alerts in a hospital setting. However, reporting on models' development and validation should be improved, and external validation and implementation in hospital practice should be encouraged.

Indexed as

Artificial IntelligenceDecision Support Systems, ClinicalMedical Order Entry SystemsHumansMedication Errorsartificial intelligenceclinical decision support systemsmedication alertsmedication safety

Identifiers

PMID38641410
PMCPMC11105146
OpenAlexW4394975263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.