ArticleNeuron2024
Preferences reveal dissociable encoding across prefrontal-limbic circuits.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach-avoidance decision-making.Nature neuroscience · 2026Article
- Brain activity, disruption and connectivity comparisons identify origins of human metacognition in other primates.Nature human behaviour · 2026Article
- Identity-specific reward expectations in orbitofrontal cortex guide goal-directed choices.PLoS biology · 2026Article
- Dynamic geometry remapping of neural activity within frontal and subcortical areas during decision-making.bioRxiv : the preprint server for biology · 2026Article
- Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey.Scientific data · 2026Article
- Value coding by primate amygdala neurons complies with the continuity axiom of economic choice theory.Journal of neurophysiology · 2026Article
- Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques.Nature communications · 2026Article
- Using economic value signals from primate prefrontal cortex in neuro-engineering applications.Journal of neural engineering · 2025Article
- Preferences for fat, sugar, and oral-sensory food qualities in monkeys and humans.Physiology & behavior · 2025Review
- Fronto-motor circuits linked to effort-based decision-making and apathy in healthy subjects.Communications biology · 2025Article
- Orbitofrontal cortex computes gaze-dependent comparisons between attributes rather than integrated values.PLoS biology · 2025Article
- Adaptive reward representations integrate expected uncertainty signals in orbitofrontal cortex.Science advances · 2025Article
- Chemogenetic inhibition of amygdala to ventrolateral prefrontal cortex communication selectively impacts contingent learning.bioRxiv : the preprint server for biology · 2025Article
- Consistent Hierarchies of Single-Neuron Timescales in Mice, Macaques, and Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.Nature communications · 2025Article
- The curious case of dopaminergic prediction errors and learning associative information beyond value.Nature reviews. Neuroscience · 2025Review
- Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses.Neuron · 2024Article
- Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex.Current biology : CB · 2024Article
- Dissociable Representations of Decision Variables within Subdivisions of the Macaque Orbital and Ventrolateral Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex.bioRxiv : the preprint server for biology · 2024Article
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Abstract
Individual preferences for the flavor of different foods and fluids exert a strong influence on behavior. Most current theories posit that preferences are integrated with other state variables in the orbitofrontal cortex (OFC), which is thought to derive the relative subjective value of available options to guide choice behavior. Here, we report that instead of a single integrated valuation system in the OFC, another complementary one is centered in the ventrolateral prefrontal cortex (vlPFC) in macaques. Specifically, we found that the OFC and vlPFC preferentially represent outcome flavor and outcome probability, respectively, and that preferences are separately integrated into value representations in these areas. In addition, the vlPFC, but not the OFC, represented the probability of receiving the available outcome flavors separately, with the difference between these representations reflecting the degree of preference for each flavor. Thus, both the vlPFC and OFC exhibit dissociable but complementary representations of subjective value, both of which are necessary for decision-making.
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