Evidence map›Paper›PMID 38640889›Full record

ArticleMolecular cell2024

Human DNA polymerase θ does not harbor intrinsic nuclease activity.

Denisse Carvajal-Maldonado, Karl Zahn, Ryan Jensen, Richard D Wood, Sylvie Doublié

Open access · greenAbstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Mini-Hairpin DNA: Extraordinarily Stable Structure and Its Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Coordinated transfer of DNA between Pol θ and Pol δ resets microhomology choice during double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Denisse Carvajal-MaldonadoDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Center, Houston, TX, USA.
Karl ZahnRepare Therapeutics, 7210 rue Frederick-Banting bureau 100, Saint-Laurent, QC H4S 2A1, Canada.
Ryan JensenDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA.
Richard D WoodDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Center, Houston, TX, USA. Electronic address: rwood@mdanderson.org.
Sylvie DoubliéDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, USA. Electronic address: sylvie.doublie@uvm.edu.
The University of Texas MD Anderson Cancer Center · USTelesta Therapeutics (Canada) · CAUniversity of Vermont · USYale University · US

Funding

Structural determinants of Pol theta functionP01CA247773 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DALE A RAMSDEN · 2020 to 2026
$15.2M
NCI NIH HHS P01 CA247773
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA-Directed DNA PolymeraseDNA Polymerase thetaHumansMutationDNA-Directed DNA PolymeraseDNA Polymerase thetaPOLQ protein, human

Identifiers

PMID38640889
PMCPMC11781231
OpenAlexW4394935715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.