Evidence map›Paper›PMID 38640789›Full record

ArticleVirology2024

Major open questions in the hepatitis B and D field - Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop.

Thomas Tu, Jochen Wettengel, Yuchen Xia, Barbara Testoni, Margaret Littlejohn, Nina Le Bert, Gregor Ebert, Eloi R Verrier, John E Tavis, Chari Cohen

Open access · greenAbstract read
In one paragraph

Article in Virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 6 countries.

Thomas TuStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney at Westmead Hospital, Westmead, NSW, Australia; Centre for Infectious Diseases and Microbiology, Sydney Infectious Diseases Institute, The University of Sydney at Westmead Hospital, Westmead, NSW, Australia. Electronic address: t.tu@sydney.edu.au.
Jochen WettengelDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, 97006, USA; Institute of Virology, Technical University of Munich /Helmholtz Munich, Munich, Germany; German Center for Infection Research, Munich Partner Site, 81675, Munich, Germany.
Yuchen XiaState Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China; Hubei Jiangxia Laboratory, Wuhan, China; Pingyuan Laboratory, Henan, China.
Barbara TestoniINSERM U1052, CNRS UMR-5286, Cancer Research Center of Lyon, Lyon, France; University of Lyon, Université Claude-Bernard, Lyon, France; Hepatology Institute of Lyon, France.
Margaret LittlejohnVictorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital and Department of Infectious Disease, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Nina Le BertProgram in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Gregor EbertInstitute of Virology, Technical University of Munich /Helmholtz Munich, Munich, Germany.
Eloi R VerrierUniversity of Strasbourg, Inserm, Institute for Translational Medicine and Liver Disease, UMR_S1110, Strasbourg, France.
John E TavisDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine and the Saint Louis University Institute for Drug and Biotherapeutic Innovation, Saint Louis, MO, USA.
Chari CohenHepatitis B Foundation, Doylestown, PA, USA.
Duke-NUS Medical School · SGHelmholtz Zentrum München · DEHepatitis B Foundation · USInserm · FROregon National Primate Research Center · USSaint Louis University · USThe Royal Melbourne Hospital · AUThe University of Sydney · AUUniversité Claude Bernard Lyon 1 · FRWuhan University · CN

Funding

Lead optimization of Hepatitis B Virus ribonuclease H inhibitorsR01AI150610 · NIAID · SAINT LOUIS UNIVERSITY · PI MEYERS, MARVIN J, TAVIS, JOHN E · 2021 to 2025
$3.3M
HBV RNaseH inhibitors: Effects on HBV biology and resistance developmentR01AI148362 · NIAID · SAINT LOUIS UNIVERSITY · PI TAVIS, JOHN E · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI148362NIAID NIH HHS R01 AI150610
6 · The paper itself

Abstract

The early and mid-career researchers (EMCRs) of scientific communities represent the forefront of research and the future direction in which a field takes. The opinions of this key demographic are not commonly aggregated to audit fields and precisely demonstrate where challenges lie for the future. To address this, we initiated the inaugural International Emerging Researchers Workshop for the global Hepatitis B and Hepatitis D scientific community (75 individuals). The cohort was split into small discussion groups and the significant problems, challenges, and future directions were assessed. Here, we summarise the outcome of these discussions and outline the future directions suggested by the EMCR community. We show an effective approach to gauging and accumulating the ideas of EMCRs and provide a succinct summary of the significant gaps remaining in the Hepatitis B and Hepatitis D field.

Indexed as

Hepatitis BHepatitis DBiomedical ResearchHepatitis B virusHumansResearch PersonnelChallengesEarly and mid-career researchersEmerging researchersHepatitis BHepatitis DHepatocellular carcinomaProfessional development

Identifiers

PMID38640789
PMCPMC11517827
OpenAlexW4394840092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.