Evidence map›Paper›PMID 38640735›Full record

ArticleBiochemical and biophysical research communications2024

Stasimon/Tmem41b is required for cell proliferation and adult mouse survival.

Maria J Carlini, Meaghan Van Alstyne, Hua Yang, Shubhi Yadav, Neil A Shneider, Livio Pellizzoni

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maria J CarliniCenter for Motor Neuron Biology and Disease, Columbia University, New York, NY, 10032, USA; Department of Neurology, Columbia University, New York, NY, 10032, USA.
Meaghan Van AlstyneCenter for Motor Neuron Biology and Disease, Columbia University, New York, NY, 10032, USA; Department of Neurology, Columbia University, New York, NY, 10032, USA.
Hua YangCenter for Motor Neuron Biology and Disease, Columbia University, New York, NY, 10032, USA; Department of Neurology, Columbia University, New York, NY, 10032, USA.
Shubhi YadavCenter for Motor Neuron Biology and Disease, Columbia University, New York, NY, 10032, USA; Department of Neurology, Columbia University, New York, NY, 10032, USA.
Neil A ShneiderCenter for Motor Neuron Biology and Disease, Columbia University, New York, NY, 10032, USA; Department of Neurology, Columbia University, New York, NY, 10032, USA.
Livio PellizzoniCenter for Motor Neuron Biology and Disease, Columbia University, New York, NY, 10032, USA; Department of Neurology, Columbia University, New York, NY, 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA. Electronic address: lp2284@cumc.columbia.edu.
Columbia University Irving Medical Center · US

Funding

High-throughput targeted mutagenesis of mouse stem cell linesU01HG004080 · NHGRI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI DE JONG, PIETER J. · 2006 to 2010
$28.1M
RNA-Mediated Mechanisms of Motor System Dysfunction in Spinal Muscular AtrophyR01NS102451 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Livio Pellizzoni · 2017 to 2026
$3.9M
Essential role of Stasimon in motor circuit development and diseaseR01NS114218 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PELLIZZONI, LIVIO · 2020 to 2024
$2.9M
Mechanisms and Therapeutic Targeting of Motor Neuron Death in SMAR01NS116400 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PELLIZZONI, LIVIO · 2020 to 2024
$2.3M
NHGRI NIH HHS U01 HG004080NINDS NIH HHS R01 NS102451NINDS NIH HHS R01 NS114218NINDS NIH HHS R01 NS116400Wellcome Trust
6 · The paper itself

Abstract

Stasimon/Tmem41b is a transmembrane protein with phospholipid scrambling activity that resides in the endoplasmic reticulum and has been implicated in autophagy, lipid metabolism, and viral replication. Stasimon/Tmem41b has also been linked to the function of sensory-motor circuits and the pathogenesis of spinal muscular atrophy. However, the early embryonic lethality of constitutive knockout in mice has hindered the analysis of spatial and temporal requirements of Stasimon/Tmem41b in vivo. To address this, we developed a novel mouse line harboring a conditional knockout allele of the Stasimon/Tmem41b gene in which exon 4 has been flanked by loxP sites (Stas/Tmem41b

Indexed as

Cell ProliferationMembrane ProteinsAnimalsFibroblastsMiceMice, Inbred C57BLMice, KnockoutMembrane ProteinsTmem41b protein, mouseCell proliferationEndoplasmic reticulum (ER)Lipid homeostasisPhospholipid scramblaseSpinal muscular atrophy (SMA)Stasimon/Tmem41b

Identifiers

PMID38640735
PMCPMC11066899
OpenAlexW4394858497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.