Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024
Laparoscopic Versus Open Hemihepatectomy: The ORANGE II PLUS Multicenter Randomized Controlled Trial.
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- The E-AHPBA-ESSO-Innsbruck consensus recommendations on peri- and postoperative management following liver resection.The British journal of surgery · 2025Guideline
- Robotic versus laparoscopic liver resection for difficult posterosuperior segments: a systematic review with a meta-analysis of propensity-score matched studies.Surgical endoscopy · 2025Pooled it
- Laparoscopic versus open hemihepatectomy: does side matter? A post-hoc analysis of the ORANGE II PLUS randomized controlled trial.Surgical endoscopy · 2026Trial
- Healthcare Utilization, Costs, and Cost-Effectiveness of Patients Undergoing Laparoscopic and Open Hemihepatectomy: A Secondary Analysis of the ORANGE II PLUS Randomized Controlled, Phase 3, Superiority Trial.Annals of surgical oncology · 2026Trial
- Effects of Dexmedetomidine on Minimum Alveolar Concentration of Sevoflurane for Blunting Sympathetic Response to Pneumoperitoneum: A Randomized Trial.Drug design, development and therapy · 2025Trial
- Robotic liver resection learning curves stratified by IWATE criteria.Surgical endoscopy · 2026Article
- Safety and efficacy of robotic repeat hepatectomy compared to laparoscopic and open repeat hepatectomy: a retrospective comparative study.Updates in surgery · 2026Article
- Minimally invasive bioelectronic implants.Nature materials · 2026Review
- Review
- Robotic versus laparoscopic anatomical hepatectomy: a post hoc analysis of the ROC'N'ROLL randomized controlled trial.Surgical endoscopy · 2026Article
- Laparoscopic or Open Liver Resection Versus Multibipolar Radiofrequency Ablation of HCC Within Milan Criteria on Cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Conversion in Minimally Invasive Liver Surgery: The Impact of Conversion Urgency and Surgical Approach.Annals of surgical oncology · 2026Article
- LaparoscopicAnnals of surgical treatment and research · 2026Article
- Refining the boundaries of resectability for colorectal cancer liver metastases with extrahepatic disease-surgical lessons from a nationwide analysis.Hepatobiliary surgery and nutrition · 2026Article
- [Influencing factors and results of conversions in minimally invasive liver surgery : A single-center analysis of over 1200 consecutive cases].Chirurgie (Heidelberg, Germany) · 2026Article
- Better outcomes of robotic liver resection in segment VII/VIII compared to open and laparoscopic approach.Journal of robotic surgery · 2026Article
- The Cost of Progress that Pays Off.Annals of surgical oncology · 2026Article
- Robotic Hepatectomy for Primary Liver Cancer.Annals of surgical oncology · 2026Review
- Robotic Hepatectomy for Primary Liver Cancer.Annals of surgical oncology · 2026Review
- Laparoscopic versus open minor liver resections of colorectal cancer liver metastases in a state at war: A prospective cohort study.Surgery open science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 17 institutions in 6 countries.
Funding
Abstract
purposeTo compare outcomes after laparoscopic versus open major liver resection (hemihepatectomy) mainly for primary or metastatic cancer. The primary outcome measure was time to functional recovery. Secondary outcomes included morbidity, quality of life (QoL), and for those with cancer, resection margin status and time to adjuvant systemic therapy. PATIENTS AND
methodsThis was a multicenter, randomized controlled, patient-blinded, superiority trial on adult patients undergoing hemihepatectomy. Patients were recruited from 16 hospitals in Europe between November 2013 and December 2018.
resultsOf the 352 randomly assigned patients, 332 patients (94.3%) underwent surgery (laparoscopic, n = 166 and open, n = 166) and comprised the analysis population. The median time to functional recovery was 4 days (IQR, 3-5; range, 1-30) for laparoscopic hemihepatectomy versus 5 days (IQR, 4-6; range, 1-33) for open hemihepatectomy (difference, -17.5% [96% CI, -25.6 to -8.4];
conclusionAmong patients undergoing hemihepatectomy, the laparoscopic approach resulted in a shorter time to functional recovery compared with open surgery. In addition, it was associated with a better QoL, and in patients with cancer, a shorter time to adjuvant systemic therapy with no adverse impact on cancer outcomes observed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.