Evidence map›Paper›PMID 38640253›Full record

ArticleScience immunology2024

TIM-3

Simone A Minnie, Olivia G Waltner, Ping Zhang, Shuichiro Takahashi, Nicole S Nemychenkov, Kathleen S Ensbey, Christine R Schmidt, Samuel R W Legg, Melissa Comstock, Julie R Boiko and 11 more

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. AblatingFrontiers in immunology · 2026
    Article
  18. EomesoderminImmunity · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Simone A MinnieTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-1314-9264
Olivia G WaltnerTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-7021-0431
Ping ZhangTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-0311-6725
Shuichiro TakahashiTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-3850-0559
Nicole S NemychenkovTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Kathleen S EnsbeyTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Christine R SchmidtTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0003-2051-0825
Samuel R W LeggTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Melissa ComstockTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0004-0393-9571
Julie R BoikoTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0008-1378-4752
Ethan NelsonTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Shruti S BhiseTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Alec B WilkensTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-8721-9133
Motoko KoyamaTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0003-6097-1204
Madhav V DhodapkarDepartment of Hematology/Medical Oncology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-8249-5988
Marta ChesiDepartment of Medicine, Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ, USA.ORCID 0000-0002-4024-8225
Stanley R RiddellTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-4688-9920
Damian J GreenTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-0477-1446
Andrew SpencerAustralian Center for Blood Diseases, Monash University/Alfred Hospital, Melbourne, VIC, Australia.ORCID 0000-0002-0531-7424
Scott N FurlanTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-3007-9840
Geoffrey R HillTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-2994-0429
Fred Hutch Cancer Center · USUniversity of Washington Medical Center · USUniversity of Washington · USEmory University · USMayo Clinic in Arizona · USThe Alfred Hospital · AU

Funding

Project 3: Stem Cell Allografts for Lymphoid MalignanciesP01CA078902 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SANDMAIER, BRENDA MARIE · 1999 to 2025
$46.1M
Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Peter Leif Bergsagel · 2015 to 2026
$25.5M
NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
PEDIATRIC ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009351 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth R Lawlor, SOHEIL MESHINCHI · 1985 to 2026
$7.0M
Preventing Myeloma Relapse after Autologous Stem Cell Transplantation with Decoy Resistant IL-18U01CA244291 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HILL, GEOFFREY ROGER · 2019 to 2022
$4.2M
preclinical optimization of BCMA directed T cell therapyR01CA272426 · NCI · MAYO CLINIC ARIZONA · PI Peter Leif Bergsagel, Marta Chesi · 2023 to 2026
$2.5M
High-Performance Compute Cluster for Comprehensive Cancer and Infectious Diseases ResearchS10OD028685 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BRADLEY, PHILIP · 2020 to 2020
$2.0M
Credentialing a Genetically Engineered Clinically-Relevant Mouse Model of Multiple MyelomaR01CA234181 · NCI · MAYO CLINIC ARIZONA · PI CHESI, MARTA · 2019 to 2023
$1.9M
NCATS NIH HHS KL2 TR002317NCI NIH HHS P01 CA078902NCI NIH HHS P50 CA186781NCI NIH HHS R01 CA234181NCI NIH HHS R01 CA272426NCI NIH HHS T32 CA009351NCI NIH HHS U01 CA244291NIH HHS S10 OD028685
6 · The paper itself

Abstract

Chronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here, we identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an apparent terminally exhausted phenotype (T

Indexed as

Hematologic NeoplasmsMultiple MyelomaCD8-Positive T-LymphocytesHepatitis A Virus Cellular Receptor 2HumansPhenotypeTumor MicroenvironmentHepatitis A Virus Cellular Receptor 2

Identifiers

PMID38640253
PMCPMC11093588
OpenAlexW4394963672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.