ArticleScience immunology2024
Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
16.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Efficacy of Advanced Therapies in Achieving Remission by Disease Location in Crohn's Disease: A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Pooled it
- Multiomic characterisation of the clinical efficacy of guselkumab induction therapy in ulcerative colitis.BMJ open gastroenterology · 2026Trial
- Unraveling the drug resistance web in IBD: The gut microbiota-immunity-epigenetics axis.Gut microbes · 2026Review
- Engineering immune cell therapies for inflammatory bowel disease: from stem cells to CAR T cells.Nature reviews. Gastroenterology & hepatology · 2026Review
- Single-cell spatial transcriptomics of formalin-fixed, paraffin-embedded biopsies reveals colitis-associated cell networks.The Journal of clinical investigation · 2026Article
- Atlas of human gut-associated lymphoid tissue reveals immunomodulatory interactions of B cells.Science immunology · 2026Article
- Review
- Decoding ulcerative colitis pathogenesis through transcriptomics: from dysregulated gene networks to targeted intervention strategies.Journal of translational autoimmunity · 2026Article
- Classic hodgkin lymphoma associated with Epstein-Barr virus reactivation during vedolizumab therapy for ulcerative colitis.Clinical journal of gastroenterology · 2026Article
- JAK inhibitors alleviate EGFR-inhibitor-induced diarrhea by protecting intestinal stem cells from adaptive-immune-exacerbated injury.Nature communications · 2026Article
- Mucosal B Cell Expansion and Maturation Contribute to Colitis Pathogenesis.Inflammatory bowel diseases · 2026Article
- Lymphocyte homing disorder: a concealed driver of intestinal immune collapse in sepsis.Frontiers in immunology · 2026Review
- Effect of curcumin combined with vedolizumab on disease activity in patients with moderate to severe ulcerative colitis and its correlation with inflammatory and immune factors.Frontiers in medicine · 2026Article
- Spatial multi-omics-guided drug development in inflammatory bowel disease: from mucosal immune niches to precision therapy.Frontiers in immunology · 2026Review
- Bovine Lymphocyte Intestinal Retention Defect (BLIRD): a novel recessive immunogenetic disorder in Holstein cattle.The veterinary quarterly · 2025Article
- Dietary Polyphenols-Gut Microbiota Interactions: Intervention Strategies and Metabolic Regulation for Intestinal Diseases.Biology · 2025Review
- Serum proteomic and metabolomic analyses from patients with IBD identify biological pathways associated with treatment success with anti-integrin therapy.Immunology and cell biology · 2025Article
- Integrin α4β7 as a predictor of HIV acquisition: one thread in a complex tapestry.The Journal of clinical investigation · 2025Article
- Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease.Nature immunology · 2025Review
- Systems Human Immunology and AI: Immune Setpoint and Immune Health.Annual review of immunology · 2025Review
Corrections and comments
- Update of
Authors and funding
45 authors at 9 institutions in 4 countries.
Pablo Canales-HerreriasPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-1865-6476
Mathieu UzzanPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7761-2879
Akihiro SekiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-0356-1810
Rafael S CzepielewskiDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2475-3838
Bram VerstocktDepartment of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0003-3898-7093
Alexandra E LivanosPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8418-3400
Fiona RasoDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-9677-5801
Alexandra DunnPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel DaiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-2522-6084
Andrew WangPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-8018-3828
Zainab Al-TaieDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-2624-2035
Jerome MartinPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Thomas LaurentNantes Université, CHU Nantes, Inserm, Centre de Recherche Translationelle en Transplantation et Immunologie, UMR 1064, Nantes, France.
Huaibin M KoDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-1062-2383
Minami TokuyamaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6488-9687
Michael TankelevichPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hadar MeringerPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-2624-2505
Francesca CossariniPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8793-5241
Divya JhaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5038-241X
Azra KrekDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0001-7845-9984
John D PaulsenDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6525-9126
Matthew D TaylorPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mohammad Zuber NakadarDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0002-2946-0978
Joshua WongDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emma C ErlichDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-2584-1407
Rachel L MintzDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
Emily J OnuferDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8802-5346
Beth A HelminkDepartment of Surgery, Section of Surgical Oncology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8206-0351
Keshav SharmaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adam RosensteinPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Danielle GanjianPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Grace ChungHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7101-6865
Travis DawsonHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9609-793X
Julius JuarezTakeda Pharmaceuticals, Cambridge, MA, USA.
Vijay YajnikTakeda Pharmaceuticals, Cambridge, MA, USA.ORCID 0000-0001-6767-1712
Andrea CeruttiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3026-4704
Jeremiah J FaithPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-2691-4500
Mayte Suarez-FarinasDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carmen ArgmannDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francesca PetraliaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gwendalyn J RandolphDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9045-1195
Alexandros D PolydoridesHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-8604-0756
Andrea ReboldiDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-1137-6292
Jean-Frederic ColombelHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6472-249X
Saurabh MehandruPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9781-2969
Icahn School of Medicine at Mount Sinai · USWashington University in St. Louis · USInserm · FRTakeda (United States) · USUniversity of Massachusetts Chan Medical School · USInstitució Catalana de Recerca i Estudis Avançats · ESKU Leuven · BESt. Louis Children's Hospital · USUniversité Paris-Est Créteil · FR
Funding
Determination of mucosal immune responses to, and infection of the gastrointestinal tract by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)R01DK123749 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA, FAITH, JEREMIAH JAMES · 2020 to 2024
$4.9MDefining the lymphatic basis of protein losing enteropathy after Fontan palliation or inflammatory gut diseaseDP1DK130660 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2021 to 2025
$3.8MMechanisms that alter lymphatic transport in inflammatory bowel diseaseR01AI168044 · NIAID · WASHINGTON UNIVERSITY · PI Gwendalyn J Randolph · 2022 to 2026
$2.8MGut region-specific mechanisms that limit dissemination of microbial signals from the intestineU01AI163064 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2021 to 2025
$2.2MTraining in the Molecular Basis of Autoimmunity and AutoinflammationT32AI132152 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2018 to 2026
$1.6MTraining African giant rats as a cheap diagnostic tool for early TB detectionR03AI068044 · NIAID · APOPO VZW · PI WEETJENS, BART J · 2006 to 2008
$170kNIAID NIH HHS R01 AI168044NIAID NIH HHS R03 AI068044NIAID NIH HHS T32 AI132152NIAID NIH HHS U01 AI163064NIDDK NIH HHS DP1 DK130660NIDDK NIH HHS R01 DK123749
Abstract
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in naïve B and T cells in the intestines and gut-homing (β7
Indexed as
Colitis, UlcerativeAnimalsHumansImmunoglobulin GIntegrinsIntestinal MucosaMicePeyer's PatchesImmunoglobulin GIntegrins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.